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Increased Expression of UMAMIT Amino Acid Transporters Results in Activation of Salicylic Acid Dependent Stress Response

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dc.contributor.authorBesnard, Julienen
dc.contributor.authorSonawala, Unnatien
dc.contributor.authorMaharjan, Balen
dc.contributor.authorCollakova, Evaen
dc.contributor.authorFinlayson, Scott A.en
dc.contributor.authorPilot, Guillaumeen
dc.contributor.authorMcDowell, John M.en
dc.contributor.authorOkumoto, Sakikoen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2021-06-01T14:49:03Zen
dc.date.available2021-06-01T14:49:03Zen
dc.date.issued2021-01-26en
dc.description.abstractIn addition to their role in the biosynthesis of important molecules such as proteins and specialized metabolites, amino acids are known to function as signaling molecules through various pathways to report nitrogen status and trigger appropriate metabolic and cellular responses. Moreover, changes in amino acid levels through altered amino acid transporter activities trigger plant immune responses. Specifically, loss of function of major amino acid transporter, over-expression of cationic amino acid transporter, or over-expression of the positive regulators of membrane amino acid export all lead to dwarfed phenotypes and upregulated salicylic acid (SA)-induced stress marker genes. However, whether increasing amino acid exporter protein levels lead to similar stress phenotypes has not been investigated so far. Recently, a family of transporters, namely USUALLY MULTIPLE ACIDS MOVE IN AND OUT TRANSPORTERS (UMAMITs), were identified as amino acid exporters. The goal of this study was to investigate the effects of increased amino acid export on plant development, growth, and reproduction to further examine the link between amino acid transport and stress responses. The results presented here show strong evidence that an increased expression of UMAMIT transporters induces stress phenotypes and pathogen resistance, likely due to the establishment of a constitutive stress response via a SA-dependent pathway.en
dc.description.notesThis work was supported by the National Science Foundation MCB 1052048 (SO), IOS 135336 (GP, JM, and SO), Virginia Agricultural Experiment Station and the Hatch Program of the National Institute of Food and Agriculture, U.S. Department of Agriculture, projects VA-135908, VA-160087 (GP), VA-160106 (JM), and VA-160050 (EC).en
dc.description.sponsorshipNational Science FoundationNational Science Foundation (NSF) [MCB 1052048, IOS 135336]; Virginia Agricultural Experiment Station; Hatch Program of the National Institute of Food and Agriculture, U.S. Department of Agriculture [VA-135908, VA-160087, VA-160106, VA-160050]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fpls.2020.606386en
dc.identifier.issn1664-462Xen
dc.identifier.other606386en
dc.identifier.pmid33574824en
dc.identifier.urihttp://hdl.handle.net/10919/103554en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmembrane transporten
dc.subjectamino acid transporten
dc.subjectamino acid metabolismen
dc.subjectstress responseen
dc.subjectsalicylic aciden
dc.titleIncreased Expression of UMAMIT Amino Acid Transporters Results in Activation of Salicylic Acid Dependent Stress Responseen
dc.title.serialFrontiers in Plant Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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