Targeting protein-protein interaction interfaces in COVID-19 drug discovery

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dc.contributor.authorChang, Chung-Keen
dc.contributor.authorLin, Shan-Mengen
dc.contributor.authorRoshan, Satangeen
dc.contributor.authorLin, Shih-Chaoen
dc.contributor.authorSun, Sin-Cihen
dc.contributor.authorHung-Yi, Wuen
dc.contributor.authorKehn-Hall, Kyleneen
dc.contributor.authorHou, Ming-Honen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-07-09T16:35:03Zen
dc.date.available2021-07-09T16:35:03Zen
dc.date.issued2021-04-15en
dc.description.abstractTo date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the SARS-CoV-2. Targeting relevant protein-protein interaction interfaces (PPIIs) is a viable paradigm for the design of antiviral drugs and enriches the targetable chemical space by providing alternative targets for drug discovery. In this review, we will provide a comprehensive overview of the theory, methods and applications of PPII-targeted drug development towards COVID-19 based on recent literature. We will also highlight novel developments, such as the successful use of non-native protein-protein interactions as targets for antiviral drug screening. We hope that this review may serve as an entry point for those interested in applying PPIIs towards COVID-19 drug discovery and speed up drug development against the pandemic.en
dc.description.sponsorshipThis work was supported by the MOST 109-2327-B-005 -005 and 109ST001C from ENABLE Center, NCHU.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.csbj.2021.04.003en
dc.identifier.urihttp://hdl.handle.net/10919/104125en
dc.identifier.volume19en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCOVID-19en
dc.subjectPPIIsen
dc.subjectAntiviral strategyen
dc.subjectDrug discoveryen
dc.subjectSARS-CoV-2en
dc.titleTargeting protein-protein interaction interfaces in COVID-19 drug discoveryen
dc.title.serialComputational and Structural Biotechnology Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Biomedical Sciences and Pathobiology
Destination Area: Global Systems Science (GSS)