Application of sub-micrometer vibrations to mitigate bacterial adhesion

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dc.contributor.authorPaces, Will R.en
dc.contributor.authorHolmes, Hal R.en
dc.contributor.authorVlaisavljevich, Elien
dc.contributor.authorSnyder, Katherine L.en
dc.contributor.authorTan, Ee Limen
dc.contributor.authorRajachar, Rupak M.en
dc.contributor.authorOng, Keat Gheeen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.coverage.spatialSwitzerlanden
dc.date.accessioned2017-11-14T21:01:08Zen
dc.date.available2017-11-14T21:01:08Zen
dc.date.issued2014-03-11en
dc.description.abstractAs a prominent concern regarding implantable devices, eliminating the threat of opportunistic bacterial infection represents a significant benefit to both patient health and device function. Current treatment options focus on chemical approaches to negate bacterial adhesion, however, these methods are in some ways limited. The scope of this study was to assess the efficacy of a novel means of modulating bacterial adhesion through the application of vibrations using magnetoelastic materials. Magnetoelastic materials possess unique magnetostrictive property that can convert a magnetic field stimulus into a mechanical deformation. In vitro experiments demonstrated that vibrational loads generated by the magnetoelastic materials significantly reduced the number of adherent bacteria on samples exposed to Escherichia coli, Staphylococcus epidermidis and Staphylococcus aureus suspensions. These experiments demonstrate that vibrational loads from magnetoelastic materials can be used as a post-deployment activated means to deter bacterial adhesion and device infection.en
dc.description.versionPublished versionen
dc.format.extent15 - 26 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3390/jfb5010015en
dc.identifier.issn2079-4983en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/80390en
dc.identifier.volume5en
dc.language.isoenen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/24956354en
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.titleApplication of sub-micrometer vibrations to mitigate bacterial adhesionen
dc.title.serialJournal of Functional Biomaterialsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dcterms.dateAccepted2014-02-28en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen

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