VTechWorks staff will be away for the winter holidays starting Tuesday, December 24, 2024, through Wednesday, January 1, 2025, and will not be replying to requests during this time. Thank you for your patience, and happy holidays!
 

Protective Effects of Extracts from Fructus rhodomyrti against Oxidative DNA Damage In Vitro and In Vivo

Simple item page
dc.contributor.authorKe, Yuebinen
dc.contributor.authorXu, Xinyunen
dc.contributor.authorWu, Shuangen
dc.contributor.authorHuang, Juanen
dc.contributor.authorGeng, Yijieen
dc.contributor.authorMisra, Hara P.en
dc.contributor.authorLi, Yunboen
dc.date.accessioned2017-09-18T09:45:06Zen
dc.date.available2017-09-18T09:45:06Zen
dc.date.issued2013-09-05en
dc.date.updated2017-09-18T09:45:06Zen
dc.description.abstractObjective. To evaluate the potential protective effects of extracts from Fructus rhodomyrti (FR) against oxidative DNA damage using a cellular system and the antioxidant ability on potassium bromate- (KBrO3-) mediated oxidative stress in rats. Methods. The effects of FR on DNA damage induced by hydrogen peroxide (H2O2) were evaluated by comet assay in primary spleen lymphocytes cultures. The effects of FR on the activities of SOD, CAT, and GPx and the levels of GSH, hydroperoxides, and 8-OHdG were determined in the plasma and tissues of rats treated with KBrO3. Results. FR was shown to effectively protect against DNA damage induced by H2O2  in vitro, and the maximum protective effect was observed when FR was diluted 20 times. Endogenous antioxidant status, namely, the activities of SOD, CAT, and GPx and the levels of GSH were significantly decreased in the plasma, the liver, and the kidney of the KBrO3-treated rats, while the pretreatment of FR prevented the decreases of these parameters. In addition, the pretreatment of FR was also able to prevent KBrO3-induced increases in the levels of hydroperoxides and 8-OHdG in the plasma, the liver, and the kidney in rats. Conclusions. Our findings suggested that FR might act as a chemopreventive agent with antioxidant properties offering effective protection against oxidative DNA damage in a concentration-dependent manner in vitro and in vivo.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationYuebin Ke, Xinyun Xu, Shuang Wu, et al., “Protective Effects of Extracts from Fructus rhodomyrti against Oxidative DNA Damage In Vitro and In Vivo,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 507407, 8 pages, 2013. doi:10.1155/2013/507407en
dc.identifier.doihttps://doi.org/10.1155/2013/507407en
dc.identifier.urihttp://hdl.handle.net/10919/78978en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2013 Yuebin Ke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleProtective Effects of Extracts from Fructus rhodomyrti against Oxidative DNA Damage In Vitro and In Vivoen
dc.title.serialOxidative Medicine and Cellular Longevityen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 2 of 2
Name:
OMCL.2013.507407.xml
Size:
8.79 KB
Format:
Extensible Markup Language
Download
Thumbnail Image
Name:
OMCL.2013.507407.pdf
Size:
828.08 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Hindawi Press
Scholarly Works, Biomedical Sciences and Pathobiology
Scholarly Works, Virginia-Maryland College of Veterinary Medicine