Treatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fields

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dc.contributor.authorByron, Christopher R.en
dc.contributor.authorDeWitt, Matthew R.en
dc.contributor.authorLatouche, Eduardo L.en
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.authorRobertson, John L.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentLarge Animal Clinical Sciencesen
dc.date.accessioned2020-02-03T17:44:49Zen
dc.date.available2020-02-03T17:44:49Zen
dc.date.issued2019-08-14en
dc.description.abstractIrreversible electroporation is a proven ablation modality for local ablation of soft tissue tumors in animals and humans. However, the strongmuscle contractions associated with the electrical impulses (duration, 50–100 μs) requires the use of general anesthesia and, in most situations, application of neuromuscular blockade. As such, this technology is not used in an outpatient setting for ablating common cutaneous tumors (e.g., squamous cell carcinoma or melanoma) in humans or animals. Recently, high-frequency irreversible electroporation (H-FIRE) technology has been developed to enable electroporation of tumors without stimulation of nearby skeletal muscle. H-FIRE administers bursts of electrical pulses (duration, 0.5–2 μs) through bipolar electrodes placed in tumor parenchyma. We hypothesized that H-FIRE could be used to safely ablate superficial tumors in standing, awake horses without the need for general anesthesia. Here, we describe the treatment of superficial tumors in five horses using this novel ablation therapy without the need for general anesthesia. In each case, H-FIRE therapy predictably ablated tumor volume. All patients tolerated the procedure, no complications developed, and veterinary personnel safety was maintained. The H-FIRE treatment may be useful for treatment in veterinary and human patients in an outpatient setting without the need for hospitalization, general anesthesia, and advanced monitoring techniques.en
dc.description.sponsorshipFunded by the Veterinary Memorial Fund of the Virginia- Maryland College of Veterinary Medicine.en
dc.format.extent9 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationByron CR, DeWitt MR, Latouche EL, Davalos RV and Robertson JL (2019) Treatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fields. Front. Vet. Sci. 6:265. doi: 10.3389/fvets.2019.00265en
dc.identifier.doihttps://doi.org/10.3389/fvets.2019.00265en
dc.identifier.urihttp://hdl.handle.net/10919/96685en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectHorsesen
dc.subjectcutaneous tumorsen
dc.subjectelectroporationen
dc.subjectH-FIREen
dc.subjectmodels of human diseaseen
dc.subjectfocal ablationen
dc.subjectnon-thermal tumor ablationen
dc.titleTreatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fieldsen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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