Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide

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dc.contributor.authorTang, Zitingen
dc.contributor.authorShu, Gangen
dc.contributor.authorDu, Hongen
dc.contributor.authorZheng, Yileien
dc.contributor.authorFu, Hualinen
dc.contributor.authorZhang, Weien
dc.contributor.authorLv, Chengen
dc.contributor.authorXu, Funengen
dc.contributor.authorLi, Haohuanen
dc.contributor.authorOuyang, Pingen
dc.contributor.authorLin, Juchunen
dc.contributor.authorChang, Li-Jenen
dc.contributor.authorAmevor, Felix Kwameen
dc.contributor.authorZhao, Xiaolingen
dc.date.accessioned2023-02-24T15:45:42Zen
dc.date.available2023-02-24T15:45:42Zen
dc.date.issued2023-02-10en
dc.date.updated2023-02-24T14:07:46Zen
dc.description.abstractLipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic acid (FA) isolated from multiple plants exhibits multiple biological activities. This study investigated whether FA ameliorated intestinal function and microflora in LPS-challenged Tianfu broilers. The results showed that LPS challenge impaired intestinal function, as evidenced by decreased antioxidant functions (<i>p</i> &lt; 0.05), disrupted morphological structure (<i>p</i> &lt; 0.05), and increased intestinal permeability (<i>p</i> &lt; 0.05); however, these adverse effects were improved by FA supplementation. Additionally, FA supplementation preserved sIgA levels (<i>p</i> &lt; 0.05), increased mRNA expression levels of <i>CLDN</i> and <i>ZO-1</i> (<i>p</i> &lt; 0.05), and enhanced epithelial proliferation (<i>p</i> &lt; 0.05) in the ileal mucosa in LPS-challenged chickens. Moreover, FA supplementation rectified the ileal microflora disturbances in the LPS-challenged broilers. The results demonstrate that dietary FA supplementation decreased LPS-induced intestinal damage by enhancing antioxidant capacity and maintaining intestinal integrity. Furthermore, FA supplementation protects intestinal tight junctions (TJs), elevates secretory immunoglobulin A (sIgA) levels, and modulates ileal microflora composition in LPS-challenged broilers.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationTang, Z.; Shu, G.; Du, H.; Zheng, Y.; Fu, H.; Zhang, W.; Lv, C.; Xu, F.; Li, H.; Ouyang, P.; Lin, J.; Chang, L.-J.; Amevor, F.K.; Zhao, X. Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide. Molecules 2023, 28, 1720.en
dc.identifier.doihttps://doi.org/10.3390/molecules28041720en
dc.identifier.urihttp://hdl.handle.net/10919/113934en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectferulic aciden
dc.subjectlipopolysaccharideen
dc.subjectintestine permeabilityen
dc.subjectintestinal barrieren
dc.subjectileal microbiotaen
dc.titleEffects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharideen
dc.title.serialMoleculesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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