Sibling rivalry: related bacterial small RNAs and their redundant and non-redundant roles

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dc.contributor.authorCaswell, Clayton C.en
dc.contributor.authorOglesby-Sherrouse, Amanda G.en
dc.contributor.authorMurphy, Erin R.en
dc.date.accessioned2019-11-04T18:34:08Zen
dc.date.available2019-11-04T18:34:08Zen
dc.date.issued2014-10en
dc.description.abstractSmall RNA molecules (sRNAs) are now recognized as key regulators controlling bacterial gene expression, as sRNAs provide a quick and efficient means of positively or negatively altering the expression of specific genes. To date, numerous sRNAs have been identified and characterized in a myriad of bacterial species, but more recently, a theme in bacterial sRNAs has emerged: the presence of more than one highly related sRNAs produced by a given bacterium, here termed sibling sRNAs. Sibling sRNAs are those that are highly similar at the nucleotide level, and while it might be expected that sibling sRNAs exert identical regulatory functions on the expression of target genes based on their high degree of relatedness, emerging evidence is demonstrating that this is not always the case. Indeed, there are several examples of bacterial sibling sRNAs with non-redundant regulatory functions, but there are also instances of apparent regulatory redundancy between sibling sRNAs. This review provides a comprehensive overview of the current knowledge of bacterial sibling sRNAs, and also discusses important questions about the significance and evolutionary implications of this emerging class of regulators.en
dc.description.notesThe authors would like to thank the VA-MD Regional College of Veterinary Medicine and the Fralin Life Science Institute at Virginia Tech (to Clayton C. Caswell), the University of Maryland School of Pharmacy (to Amanda G. Oglesby-Sherrouse), NIH 1R15AI103887-01A1 (Erin R. Murphy) and Ohio University Heritage College of Osteopathic Medicine (Erin R. Murphy) for providing financial support for this work.en
dc.description.sponsorshipVA-MD Regional College of Veterinary Medicine; Fralin Life Science Institute at Virginia Tech; University of Maryland School of Pharmacy; Ohio University Heritage College of Osteopathic Medicine [NIH 1R15AI103887-01A1]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fcimb.2014.00151en
dc.identifier.issn2235-2988en
dc.identifier.other151en
dc.identifier.pmid25389522en
dc.identifier.urihttp://hdl.handle.net/10919/95246en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbacterial small RNAen
dc.subjectsRNAen
dc.subjectsibling sRNAen
dc.subjectribo-regulationen
dc.subjectregulationen
dc.titleSibling rivalry: related bacterial small RNAs and their redundant and non-redundant rolesen
dc.title.serialFrontiers in Cellular and Infection Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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