The T2-FLAIR mismatch sign as an imaging biomarker for oligodendrogliomas in dogs

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dc.contributor.authorGarcia-Mora, Josefaen
dc.contributor.authorParker, Rell L.en
dc.contributor.authorCecere, Thomasen
dc.contributor.authorRobertson, John L.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.date.accessioned2023-06-23T14:00:26Zen
dc.date.available2023-06-23T14:00:26Zen
dc.date.issued2023-05en
dc.description.abstractBackgroundIn humans, the T2-weighted (T2W)-fluid-attenuated inversion recovery (FLAIR) mismatch sign (T2FMM) is a specific imaging biomarker for the isocitrate dehydrogenase 1 (IDH1)-mutated, 1p/19q non-codeleted low-grade astrocytomas (LGA). The T2FMM is characterized by a homogeneous hyperintense T2W signal and a hypointense signal with a hyperintense peripheral rim on FLAIR sequences. In gliomas in dogs, the T2FMM has not been described. Hypotheses/ObjectivesIn dogs with focal intra-axial brain lesions, T2FMM will discriminate gliomas from other lesions. The T2FMM will be associated with the LGA phenotype and presence of microcysts on histopathology. Interobserver agreement for T2FMM magnetic resonance imaging (MRI) features will be high. AnimalsOne hundred eighty-six dogs with histopathologically diagnosed focal intra-axial lesions on brain MRI including oligodendrogliomas (n = 90), astrocytomas (n = 47), undefined gliomas (n = 9), cerebrovascular accidents (n = 33), and inflammatory lesions (n = 7). MethodsTwo blinded raters evaluated the 186 MRI studies and identified cases with the T2FMM. Histopathologic and immunohistochemical slides of T2FMM cases were evaluated for morphologic features and IDH1-mutations and compared to cases without the T2FMM. Gene expression analyses were performed on a subset of oligodendrogliomas (n = 10) with and without T2FMM. ResultsThe T2FMM was identified in 14/186 (8%) of MRI studies, and all dogs with T2FMM had oligodendrogliomas (n = 12 low-grade [LGO], n = 2 high-grade [HGO]; P < .001). Microcystic change was significantly associated with the T2FMM (P < .00001). In oligodendrogliomas with T2FMM, IDH1-mutations or specific differentially expressed genes were not identified. Conclusion and Clinical ImportanceThe T2FMM can be readily identified on routinely obtained MRI sequences. It is a specific biomarker for oligodendroglioma in dogs, and was significantly associated with non-enhancing LGO.en
dc.description.notesNational Institutes of Health, Grant/Award Numbers: P01CA207206, R01CA139099, R01CA213423, R01CA256285, UL1TR003015, KL2TR003016en
dc.description.sponsorshipNational Institutes of Health [P01CA207206, R01CA139099, R01CA213423, R01CA256285, UL1TR003015, KL2TR003016]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.16749en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.pmid37246729en
dc.identifier.urihttp://hdl.handle.net/10919/115497en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbrain tumoren
dc.subjectCNS disordersen
dc.subjectmagnetic resonance imagingen
dc.subjectneuroimagingen
dc.subjectneurologyen
dc.subjectoncology-diagnosisen
dc.subjectradiology and diagnostic imagingen
dc.titleThe T2-FLAIR mismatch sign as an imaging biomarker for oligodendrogliomas in dogsen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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