Association of RERG Expression with Female Survival Advantage in Malignant Pleural Mesothelioma

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dc.contributor.authorDe Rienzo, Assuntaen
dc.contributor.authorColeman, Melissa H.en
dc.contributor.authorYeap, Beow Y.en
dc.contributor.authorSeverson, David T.en
dc.contributor.authorWadowski, Benjaminen
dc.contributor.authorGustafson, Corinne E.en
dc.contributor.authorJensen, Roderick V.en
dc.contributor.authorChirieac, Lucian R.en
dc.contributor.authorRichards, William G.en
dc.contributor.authorBueno, Raphaelen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2021-02-05T17:10:32Zen
dc.date.available2021-02-05T17:10:32Zen
dc.date.issued2021-02-02en
dc.date.updated2021-02-05T14:10:08Zen
dc.description.abstractSex differences in incidence, prognosis, and treatment response have been described for many cancers. In malignant pleural mesothelioma (MPM), a lethal disease associated with asbestos exposure, men outnumber women 4 to 1, but women consistently live longer than men following surgery-based therapy. This study investigated whether tumor expression of genes associated with estrogen signaling could potentially explain observed survival differences. Two microarray datasets of MPM tumors were analyzed to discover estrogen-related genes associated with survival. A validation cohort of MPM tumors was selected to balance the numbers of men and women and control for competing prognostic influences. The RAS like estrogen regulated growth inhibitor (<i>RERG</i>) gene was identified as the most differentially-expressed estrogen-related gene in these tumors and predicted prognosis in discovery datasets. In the sex-matched validation cohort, low <i>RERG</i> expression was significantly associated with increased risk of death among women. No association between <i>RERG</i> expression and survival was found among men, and no relationship between estrogen receptor protein or gene expression and survival was found for either sex. Additional investigations are needed to elucidate the molecular mechanisms underlying this association and its sex specificity.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDe Rienzo, A.; Coleman, M.H.; Yeap, B.Y.; Severson, D.T.; Wadowski, B.; Gustafson, C.E.; Jensen, R.V.; Chirieac, L.R.; Richards, W.G.; Bueno, R. Association of RERG Expression with Female Survival Advantage in Malignant Pleural Mesothelioma. Cancers 2021, 13, 565.en
dc.identifier.doihttps://doi.org/10.3390/cancers13030565en
dc.identifier.urihttp://hdl.handle.net/10919/102275en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmalignant pleural mesotheliomaen
dc.subjectRERGen
dc.subjectsexen
dc.subjectestrogenen
dc.subjectsurvivalen
dc.titleAssociation of RERG Expression with Female Survival Advantage in Malignant Pleural Mesotheliomaen
dc.title.serialCancersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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