Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents

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dc.contributor.authorShojania Feizabadi, Mitraen
dc.contributor.committeechairSpillman, William B. Jr.en
dc.contributor.committeememberMizutani, Tetsuroen
dc.contributor.committeememberIndebetouw, Guy J.en
dc.contributor.committeememberWalker, Richard A.en
dc.contributor.committeememberRitter, Alfred L.en
dc.contributor.departmentPhysicsen
dc.date.accessioned2014-03-14T20:12:16Zen
dc.date.adate2005-06-24en
dc.date.available2014-03-14T20:12:16Zen
dc.date.issued2005-04-29en
dc.date.rdate2008-06-24en
dc.date.sdate2005-05-19en
dc.description.abstractA mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.en
dc.description.degreePh. D.en
dc.identifier.otheretd-05192005-104254en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05192005-104254/en
dc.identifier.urihttp://hdl.handle.net/10919/27795en
dc.publisherVirginia Techen
dc.relation.haspartDissertation.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectantimitotic drugsen
dc.subjectdynamic instabilityen
dc.subjectmicrotubuleen
dc.titlePhysical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agentsen
dc.typeDissertationen
thesis.degree.disciplinePhysicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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