Infectious SARS-CoV-2 Is Emitted in Aerosol Particles

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dc.contributor.authorHawks, Seth A.en
dc.contributor.authorPrussin, Aaron J. IIen
dc.contributor.authorKuchinsky, Sarah C.en
dc.contributor.authorPan, Jinen
dc.contributor.authorMarr, Linsey C.en
dc.contributor.authorDuggal, Nisha K.en
dc.date.accessioned2021-10-22T13:41:35Zen
dc.date.available2021-10-22T13:41:35Zen
dc.date.issued2021-10-19en
dc.description.abstractRespiratory viruses such as SARS-CoV-2 are transmitted in respiratory droplets and aerosol particles, which are released during talking, breathing, coughing, and sneezing. Noncontact transmission of SARS-CoV-2 has been demonstrated, suggesting transmission via virus carried through the air. Here, we demonstrate that golden Syrian hamsters produce infectious SARS-CoV-2 in aerosol particles prior to and concurrent with the onset of mild clinical signs of disease. The average emission rate in this study was 25 infectious virions/hour on days 1 and 2 postinoculation, with average viral RNA levels 200-fold higher than infectious virus in aerosol particles. The majority of virus was contained within particles <5 μm in size. Thus, we provide direct evidence that, in hamsters, SARS-CoV-2 is an airborne virus.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1128/mBio.02527-21en
dc.identifier.issue5en
dc.identifier.urihttp://hdl.handle.net/10919/105633en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectanimal modelsen
dc.subjectcoronavirusen
dc.subjecttransmissionen
dc.titleInfectious SARS-CoV-2 Is Emitted in Aerosol Particlesen
dc.title.serialmBioen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Biomedical Sciences and Pathobiology
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