Efficacy of temozolomide or dacarbazine in combination with an anthracycline for rescue chemotherapy in dogs with lymphoma

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dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorDominguez, Pedro A.en
dc.contributor.authorSarbu, Luminitaen
dc.contributor.authorNewman, Rebecca G.en
dc.contributor.authorCadile, Casey D.en
dc.contributor.authorSwanson, Christine N.en
dc.contributor.authorKitchell, Barbara E.en
dc.date.accessioned2016-11-15T20:48:34Zen
dc.date.available2016-11-15T20:48:34Zen
dc.date.issued2007-08-15en
dc.description.abstractObjective: To compare results of treatment with temozolomide or dacarbazine, in combination with an anthracycline, in dogs with relapsed or refractory lymphoma. Design: Nonrandomized, controlled clinical trial. Animals: 63 dogs with relapsed or refractory lymphoma. Procedures: Chemotherapy was administered in 21-day cycles. A combination of temozolomide and an anthracycline (doxorubicin or dactinomycin) was administered to 21 dogs and a combination of dacarbazine and an anthracycline was administered to 42 dogs. Efficacy and toxicoses were assessed. Results: Thirteen of the 18 (72%) dogs treated with the temozolomide-anthracycline combination and 25 of the 35 (71%) dogs treated with the dacarbazine-anthracycline combination had a complete or partial response. Median duration of response to rescue chemotherapy was 40 days (range, 0 to 217 days) for dogs in the temozolomide group and 50 days (range, 0 to 587 days) for dogs in the dacarbazine group. The incidence of high-grade hematologic toxicoses was significantly higher among dogs in the dacarbazine group than among dogs in the temozolomide group, but the incidence of gastrointestinal tract toxicoses was not significantly different between groups. There were no significant differences between groups in regard to proportion of dogs with a complete or partial response, duration of response to rescue chemotherapy, survival time following rescue chemotherapy, or overall survival time. Conclusions and Clinical Relevance: Both combinations had promise in the treatment of dogs with relapsed or refractory lymphoma, although administration of temozolomide was more convenient than administration of dacarbazine and caused fewer hematologic toxicoses.en
dc.description.versionPublished versionen
dc.format.extent563 - 569 (7) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2460/javma.231.4.563en
dc.identifier.issn0003-1488en
dc.identifier.issue4en
dc.identifier.urihttp://hdl.handle.net/10919/73453en
dc.identifier.volume231en
dc.language.isoenen
dc.publisherAmerican Veterinary Medical Associationen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000248646100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectPHASE-I TRIALen
dc.subjectANTITUMOR IMIDAZOTETRAZINESen
dc.subjectRESISTANT LYMPHOMAen
dc.subjectACTINOMYCIN-Den
dc.subjectDOXORUBICINen
dc.subjectTOXICITYen
dc.subjectAGENTen
dc.subjectDRUGen
dc.titleEfficacy of temozolomide or dacarbazine in combination with an anthracycline for rescue chemotherapy in dogs with lymphomaen
dc.title.serialJournal of The American Veterinary Medical Associationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherProceedings Paperen
dc.type.otherMeetingen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

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