Using host traits to predict reservoir host species of rabies virus

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dc.contributor.authorWorsley-Tonks, Katherine E. L.en
dc.contributor.authorEscobar, Luis E.en
dc.contributor.authorBiek, Romanen
dc.contributor.authorCastaneda-Guzman, Marianaen
dc.contributor.authorCraft, Meggan E.en
dc.contributor.authorStreicker, Daniel G.en
dc.contributor.authorWhite, Lauren A.en
dc.contributor.authorFountain-Jones, Nicholas M.en
dc.contributor.departmentFish and Wildlife Conservationen
dc.date.accessioned2021-08-31T14:35:39Zen
dc.date.available2021-08-31T14:35:39Zen
dc.date.issued2020-12-01en
dc.date.updated2021-08-31T14:35:35Zen
dc.description.abstractWildlife are important reservoirs for many pathogens, yet the role that different species play in pathogen maintenance frequently remains unknown. This is the case for rabies, a viral disease of mammals. While Carnivora (carnivores) and Chiroptera (bats) are the canonical mammalian orders known to be responsible for the maintenance and onward transmission of rabies Lyssavirus (RABV), the role of most species within these orders remains unknown and is continually changing as a result of contemporary host shifting. We combined a trait-based analytical approach with gradient boosting machine learning models to identify physiological and ecological host features associated with being a reservoir for RABV. We then used a cooperative game theory approach to determine species-specific traits associated with known RABV reservoirs. Being a carnivore reservoir for RABV was associated with phylogenetic similarity to known RABV reservoirs, along with other traits such as having larger litters and earlier sexual maturity. For bats, location in the Americas and geographic range were the most important predictors of RABV reservoir status, along with having a large litter. Our models identified 44 carnivore and 34 bat species that are currently not recognized as RABV reservoirs, but that have trait profiles suggesting their capacity to be or become reservoirs. Further, our findings suggest that potential reservoir species among bats and carnivores occur both within and outside of areas with current RABV circulation. These results show the ability of a trait-based approach to detect potential reservoirs of infection and could inform rabies control programs and surveillance efforts by identifying the types of species and traits that facilitate RABV maintenance and transmission.en
dc.description.versionPublished versionen
dc.format.extent21 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN e0008940 (Article number)en
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0008940en
dc.identifier.eissn1935-2735en
dc.identifier.issn1935-2735en
dc.identifier.issue12en
dc.identifier.orcidEscobar Quinonez, Luis [0000-0001-5735-2750]en
dc.identifier.otherPNTD-D-20-00634 (PII)en
dc.identifier.pmid33290391en
dc.identifier.urihttp://hdl.handle.net/10919/104879en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherPLoSen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000597934400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectInfectious Diseasesen
dc.subjectParasitologyen
dc.subjectTropical Medicineen
dc.subjectUNITED-STATESen
dc.subjectSURVEILLANCEen
dc.subjectTRANSMISSIONen
dc.subjectDYNAMICSen
dc.subjectMAINTENANCEen
dc.subjectEVOLUTIONen
dc.subjectINFECTIONen
dc.subjectHISTORYen
dc.subjectSHIFTSen
dc.subjectDOGSen
dc.subject06 Biological Sciencesen
dc.subject11 Medical and Health Sciencesen
dc.subjectTropical Medicineen
dc.subject.meshAnimalsen
dc.subject.meshChiropteraen
dc.subject.meshRabies virusen
dc.subject.meshRabiesen
dc.subject.meshDisease Reservoirsen
dc.subject.meshSpecies Specificityen
dc.subject.meshHost Specificityen
dc.subject.meshCarnivoryen
dc.titleUsing host traits to predict reservoir host species of rabies virusen
dc.title.serialPLoS Neglected Tropical Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2020-11-02en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Natural Resources & Environmenten
pubs.organisational-group/Virginia Tech/Natural Resources & Environment/Fish and Wildlife Conservationen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Natural Resources & Environment/CNRE T&R Facultyen

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