Development of a Nongenetic Mouse Model of Type 2 Diabetes

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dc.contributor.authorGilbert, Elizabeth R.en
dc.contributor.authorFu, Z.en
dc.contributor.authorLiu, D.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-01-07T23:11:30Zen
dc.date.available2017-01-07T23:11:30Zen
dc.date.issued2011-01-01en
dc.description.abstractInsulin resistance and loss of beta-cell mass cause Type 2 diabetes (T2D). The objective of this study was to generate a nongenetic mouse model of T2D. Ninety-six 6-month-old C57BL/6N males were assigned to 1 of 12 groups including (1) low-fat diet (LFD; low-fat control; LFC), (2) LFD with 1 i.p. 40 mg/kg BW streptozotocin (STZ) injection, (3), (4), (5), (6) LFD with 2, 3, 4, or 5 STZ injections on consecutive days, respectively, (7) high-fat diet (HFD), (8) HFD with 1 STZ injection, (9), (10), (11), (12) HFD with 2, 3, 4, or 5 STZ injections on consecutive days, respectively. After 4 weeks, serum insulin levels were reduced in HFD mice administered at least 2 STZ injections as compared with HFC. Glucose tolerance was impaired in mice that consumed HFD and received 2, 3, or 4 injections of STZ. Insulin sensitivity in HFD mice was lower than that of LFD mice, regardless of STZ treatment. Islet mass was not affected by diet but was reduced by 50% in mice that received 3 STZ injections. The combination of HFD and three 40 mg/kg STZ injections induced a model with metabolic characteristics of T2D, including peripheral insulin resistance and reduced beta-cell mass.en
dc.description.versionPublished versionen
dc.format.extent? - ? (12) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationElizabeth R. Gilbert, Zhuo Fu, Dongmin Liu, "Development of a Nongenetic Mouse Model of Type 2 Diabetes", Journal of Diabetes Research, vol. 2011, Article ID 416254, 12 pages, 2011. https://doi.org/10.1155/2011/416254en
dc.identifier.doihttps://doi.org/10.1155/2011/416254en
dc.identifier.issn1687-5214en
dc.identifier.urihttp://hdl.handle.net/10919/74010en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000298680600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectEndocrinology & Metabolismen
dc.subjectMedicine, Research & Experimentalen
dc.subjectResearch & Experimental Medicineen
dc.subjectBETA-CELL MASSen
dc.subjectGLUCAGON-LIKE PEPTIDE-1en
dc.subjectINCREASED APOPTOSISen
dc.subjectMICEen
dc.subjectPROLIFERATIONen
dc.subjectRATen
dc.subjectHYPERGLYCEMIAen
dc.subjectDYSLIPIDEMIAen
dc.subjectCOMBINATIONen
dc.subjectDEFECTSen
dc.titleDevelopment of a Nongenetic Mouse Model of Type 2 Diabetesen
dc.title.serialJournal of Diabetes Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
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