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Genomic analysis of two phlebotomine sand fly vectors of leishmania from the new and old World

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dc.contributor.authorLabbe, Fredericen
dc.contributor.authorAbdeladhim, Mahaen
dc.contributor.authorAbrudan, Jenicaen
dc.contributor.authorAraki, Alejandra Saorien
dc.contributor.authorAraujo, Ricardo N.en
dc.contributor.authorArensburger, Peteren
dc.contributor.authorBenoit, Joshua B.en
dc.contributor.authorBrazil, Reginaldo Pecanhaen
dc.contributor.authorBruno, Rafaela V.en
dc.contributor.authorRivas, Gustavo Bueno da Silva D. S.en
dc.contributor.authorde Abreu, Vinicius Carvalhoen
dc.contributor.authorCharamis, Jasonen
dc.contributor.authorCoutinho-Abreu, Iliano V.en
dc.contributor.authorda Costa-Latge, Samara G.en
dc.contributor.authorDarby, Alistairen
dc.contributor.authorDillon, Viv M.en
dc.contributor.authorEmrich, Scott J.en
dc.contributor.authorFernandez-Medina, Danielaen
dc.contributor.authorGontijo, Nelder Figueiredoen
dc.contributor.authorFlanley, Catherine M.en
dc.contributor.authorGatherer, Dereken
dc.contributor.authorGenta, Fernando A.en
dc.contributor.authorGesing, Sandraen
dc.contributor.authorGiraldo-Calderon, Gloria I.en
dc.contributor.authorGomes, Brunoen
dc.contributor.authorAguiar, Eric Roberto Guimaraes Rochaen
dc.contributor.authorHamilton, James GC C.en
dc.contributor.authorHamarsheh, Omaren
dc.contributor.authorHawksworth, Malloryen
dc.contributor.authorHendershot, Jacob M.en
dc.contributor.authorHickner, Paul V.en
dc.contributor.authorImler, Jean-Lucen
dc.contributor.authorIoannidis, Panagiotisen
dc.contributor.authorJennings, Emily C.en
dc.contributor.authorKamhawi, Shadenen
dc.contributor.authorKarageorgiou, Charikleiaen
dc.contributor.authorKennedy, Ryan C.en
dc.contributor.authorKrueger, Andreasen
dc.contributor.authorLatorre-Estivalis, Jose M.en
dc.contributor.authorLigoxygakis, Petrosen
dc.contributor.authorMeireles-Filho, Antonio Carlos A.en
dc.contributor.authorMinx, Patricken
dc.contributor.authorMiranda, Jose Carlosen
dc.contributor.authorMontague, Michael J.en
dc.contributor.authorNowling, Ronald J.en
dc.contributor.authorOliveira, Fabianoen
dc.contributor.authorOrtigao-Farias, Joaoen
dc.contributor.authorPavan, Marcio G.en
dc.contributor.authorPereira, Marcos Horacioen
dc.contributor.authorPitaluga, Andre Nobregaen
dc.contributor.authorOlmo, Roenick Provetien
dc.contributor.authorRamalho-Ortigao, Marceloen
dc.contributor.authorRibeiro, Jose MC C.en
dc.contributor.authorRosendale, Andrew J.en
dc.contributor.authorSant'Anna, Mauricio RV V.en
dc.contributor.authorScherer, Steven E.en
dc.contributor.authorSecundino, Nagila FC C.en
dc.contributor.authorShoue, Douglas A.en
dc.contributor.authorMoraes, Caroline da Silva D. S.en
dc.contributor.authorGesto, Joao Silveira Moledoen
dc.contributor.authorSouza, Nataly Araujoen
dc.contributor.authorSyed, Zainulabueddinen
dc.contributor.authorTadros, Samuelen
dc.contributor.authorTeles-de-Freitas, Rayaneen
dc.contributor.authorTelleria, Erich L.en
dc.contributor.authorTomlinson, Chaden
dc.contributor.authorTraub-Cseko, Yara M.en
dc.contributor.authorMarques, Joao Trindadeen
dc.contributor.authorTu, Zhijianen
dc.contributor.authorUnger, Maria F.en
dc.contributor.authorValenzuela, Jesusen
dc.contributor.authorFerreira, Flaviaen
dc.contributor.authorde Oliveira, Karla PV V.en
dc.contributor.authorVigoder, Felipe M.en
dc.contributor.authorVontas, Johnen
dc.contributor.authorWang, Lihuien
dc.contributor.authorWeedall, Gareth D.en
dc.contributor.authorZhioua, Elyesen
dc.contributor.authorRichards, Stephenen
dc.contributor.authorWarren, Wesley C.en
dc.contributor.authorWaterhouse, Robert M.en
dc.contributor.authorDillon, Rod J.en
dc.contributor.authorMcDowell, Mary Annen
dc.date.accessioned2024-01-18T13:38:59Zen
dc.date.available2024-01-18T13:38:59Zen
dc.date.issued2023-04-12en
dc.description.abstractPhlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites.en
dc.description.versionPublished versionen
dc.format.extent35 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN e0010862 (Article number)en
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0010862en
dc.identifier.eissn1935-2735en
dc.identifier.issn1935-2735en
dc.identifier.issue4en
dc.identifier.orcidTu, Zhijian [0000-0003-4227-3819]en
dc.identifier.otherPNTD-D-22-01257 (PII)en
dc.identifier.pmid37043542en
dc.identifier.urihttps://hdl.handle.net/10919/117392en
dc.identifier.volume17en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37043542en
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectLeishmaniasisen
dc.subjectSand fliesen
dc.subjectGenomic analysisen
dc.subjectParasitologyen
dc.subjectTropical Medicineen
dc.subjectVector-Borne Diseasesen
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshPsychodidaeen
dc.subject.meshPhlebotomusen
dc.subject.meshLeishmaniaen
dc.subject.meshLeishmaniasis, Cutaneousen
dc.subject.meshGenomicsen
dc.titleGenomic analysis of two phlebotomine sand fly vectors of leishmania from the new and old Worlden
dc.title.serialPLOS Neglected Tropical Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2023-02-13en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistryen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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