Intermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Model

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dc.contributor.authorEl-Kadi, Samer Wassimen
dc.contributor.authorBoutry-Regard, Claireen
dc.contributor.authorSuryawan, Agusen
dc.contributor.authorNguyen, Hanh V.en
dc.contributor.authorKimball, Scot R.en
dc.contributor.authorFiorotto, Marta L.en
dc.contributor.authorDavis, Teresa A.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2021-03-04T18:37:13Zen
dc.date.available2021-03-04T18:37:13Zen
dc.date.issued2021-01en
dc.description.abstractBackground: Orogastric tube feeding is frequently prescribed for neonates who cannot ingest food normally. In a piglet model of the neonate, greater skeletal muscle growth is sustained by upregulation of translation initiation signaling when nutrition is delivered by intermittent bolus meals, rather than continuously. Objectives: The objective of this study was to determine the long-term effects of feeding frequency on organ growth and the mechanism by which feeding frequency modulates protein anabolism in these organs. Methods: Eighteen neonatal pigs were fed by gastrostomy tube the same amount of a sow milk replacer either by continuous infusion (CON) or on an intermittent bolus schedule (INT). After 21 d of feeding, the pigs were killed without interruption of feeding (CON; n = 6) or immediately before (INT-0; n = 6) or 60 min after (INT-60; n = 6) a meal, and fractional protein synthesis rates and activation indexes of signaling pathways that regulate translation initiation were measured in the heart, jejunum, ileum, kidneys, and liver. Results: Compared with continuous feeding, intermittent feeding stimulated the growth of the liver (+64%), jejunum (+48%), ileum (+40%), heart (+64%), and kidney (+56%). The increases in heart, kidney, jejunum, and ileum masses were proportional to whole body lean weight gain, but liver weight gain was greater in the INT-60 than the CON, and intermediate for the INT-0 group. For the liver and ileum, but not the heart, kidney, and jejunum, INT-60 compared with CON pigs had greater fractional protein synthesis rates (22% and 48%, respectively) and was accompanied by an increase in ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E binding protein 1 phosphorylation. Conclusions: These results suggest that intermittent bolus compared with continuous orogastric feeding enhances organ growth and that in the ileum and liver, intermittent feeding enhances protein synthesis by stimulating translation initiation.en
dc.description.adminPublic domain – authored by a U.S. government employeeen
dc.description.notesSupported by National Institute of Arthritis and Musculoskeletal and Skin Diseases Grants AR044474 (TAD) and AR46308 (MLF), National Institute of Child Health and Human Development HD072891 (TAD), HD085573 (TAD), and HD099080 (TAD and MLF), National Institute of Diabetes and Digestive and Kidney Diseases DK15658 (SRK), United States Department of Agriculture National Institute of Agriculture grant 2013-67015-20438 (TAD), and by the USDA/ARS under Cooperative Agreement no. 3092-51000-060 (TAD).en
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [AR044474, AR46308]; National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [HD072891, HD085573, HD099080]; National Institute of Diabetes and Digestive and Kidney DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [DK15658]; United States Department of Agriculture National Institute of Agriculture [2013-67015-20438]; USDA/ARSUnited States Department of Agriculture (USDA)USDA Agricultural Research Service [3092-51000-060]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/cdn/nzaa170en
dc.identifier.issn2475-2991en
dc.identifier.issue12en
dc.identifier.othernzaa170en
dc.identifier.pmid33381676en
dc.identifier.urihttp://hdl.handle.net/10919/102612en
dc.identifier.volume4en
dc.language.isoenen
dc.rightsPublic Domainen
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/en
dc.subjectneonateen
dc.subjectNutritionen
dc.subjectpig modelen
dc.subjectliveren
dc.subjecttranslation initiationen
dc.subjectprotein synthesisen
dc.titleIntermittent Bolus Feeding Enhances Organ Growth More Than Continuous Feeding in a Neonatal Piglet Modelen
dc.title.serialCurrent Developments in Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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