Canine tonsillar squamous cell carcinoma - a multi-centre retrospective review of 44 clinical cases

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dc.contributor.authorMas, A.en
dc.contributor.authorBlackwood, L.en
dc.contributor.authorCripps, P.en
dc.contributor.authorMurphy, S.en
dc.contributor.authorde Vos, J.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorMartano, M.en
dc.contributor.authorPolton, G. A.en
dc.date.accessioned2016-11-15T20:49:37Zen
dc.date.available2016-11-15T20:49:37Zen
dc.date.issued2011-07-01en
dc.description.abstractOBJECTIVES: To review the presenting clinical signs, treatment and survival of dogs with tonsillar squamous cell carcinoma and, if possible, to identify useful prognostic indicators. METHODS: Medical records of 44 dogs were reviewed retrospectively. Clinical signs, clinical stage, time of diagnosis, treatment and outcome were recorded. Data were analysed using the Kaplan-Meier, logrank, Student’s t test, Kruskal-Wallis test and Chi-square/Fisher Exact test as appropriate. RESULTS: The most frequent clinical signs were cough (12 dogs, 27%), enlarged lymph nodes (11 dogs, 25%) and dysphagia (11 dogs, 25%). Anorexia and lethargy were less common but were significantly associated with a poor outcome. No matter what treatment modalities were used, survival times were short and median survival time for all the dogs in the study was 179 days. However, there were a small number of long-term survivors. CLINICAL SIGNIFICANCE: Dogs with tonsillar squamous cell carcinoma that suffered anorexia and lethargy had shorter survival times than patients without these clinical signs. Although surgery, chemotherapy and radiotherapy seem to increase the median survival time of dogs diagnosed with tonsillar squamous cell carcinoma, there is no highly effective treatment for canine tonsillar squamous cell carcinoma.en
dc.description.versionPublished versionen
dc.format.extent359 - 364 (6) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/j.1748-5827.2011.01075.xen
dc.identifier.issn0022-4510en
dc.identifier.issue7en
dc.identifier.urihttp://hdl.handle.net/10919/73458en
dc.identifier.volume52en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000292339200005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectORAL MALIGNANT-MELANOMAen
dc.subjectDOGSen
dc.subjectPIROXICAMen
dc.subjectCHEMOTHERAPYen
dc.subjectRADIOTHERAPYen
dc.subjectMETASTASISen
dc.subjectTUMORSen
dc.titleCanine tonsillar squamous cell carcinoma - a multi-centre retrospective review of 44 clinical casesen
dc.title.serialJournal of Small Animal Practiceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

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