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Simulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separation

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dc.contributor.authorYu, Yueyingen
dc.contributor.committeechairLiu, Yih-Anen
dc.contributor.committeememberDavis, Richey M.en
dc.contributor.committeememberBaird, Donald G.en
dc.contributor.committeememberDurrill, Preston L.en
dc.contributor.departmentChemical Engineeringen
dc.date.accessioned2017-07-08T06:00:24Zen
dc.date.available2017-07-08T06:00:24Zen
dc.date.issued2016-01-14en
dc.description.abstractThis dissertation describes the simulation and optimization of adsorptive and chromatographic separation processes. The first part focus on the simulation and comparison of operational modes in simulated moving bed (SMB) chromatography for separation and purification in bioprocesses. The second part includes the simulation of gas-phase adsorptive processes by pressure swing adsorption and temperature swing adsorption technologies. The applications of SMB chromatography are popular in separating and purifying enantiomers, petrochemicals, pharmaceuticals and biochemicals with higher yield and lower solvent consumption. We simulate and compare several operational modes of simulated moving bed (SMB) for a binary and a ternary bioprocess using Aspen Chromatography. These operational modes are able to improve the separation efficiency of the basic SMB process by our simulation and optimization. We compare their separation performances and identify heuristics that will guide the selection of operational modes across a variety of systems. Pressure swing adsorption (PSA) and temperature swing adsorption (TSA) are two of the main technologies for gas-phase adsorption separation processes. We simulate and demonstrate a PSA model for air separation system and a TSA model for CO2 capture system in Aspen Adsorption. We present their separation performance plots to provide the physical insights of these two systems.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.othervt_gsexam:6760en
dc.identifier.urihttp://hdl.handle.net/10919/78319en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectsimulated moving bed chromatographyen
dc.subjectoperational modesen
dc.subjectadsorptionen
dc.subjectSimulationen
dc.subjectOptimizationen
dc.subjectchiral separationen
dc.titleSimulation and Comparison of Operational Modes in Simulated Moving Bed Chromatography and Gas-Phase Adsorptive Separationen
dc.typeDissertationen
thesis.degree.disciplineChemical Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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