Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire

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dc.contributor.authorLévesque, C. A.en
dc.contributor.authorBrouwer, Henken
dc.contributor.authorCano, Lilianaen
dc.contributor.authorHamilton, John P.en
dc.contributor.authorHolt, Carsonen
dc.contributor.authorHuitema, Edgaren
dc.contributor.authorRaffaele, Sylvainen
dc.contributor.authorRobideau, Gregg P.en
dc.contributor.authorThines, Marcoen
dc.contributor.authorWin, Joeen
dc.contributor.authorZerillo, Marcelo M.en
dc.contributor.authorBeakes, Gordon W.en
dc.contributor.authorBoore, Jeffrey L.en
dc.contributor.authorBusam, Danaen
dc.contributor.authorDumas, Bernarden
dc.contributor.authorFerriera, Steveen
dc.contributor.authorFuerstenberg, Susan I.en
dc.contributor.authorGachon, Claire M.en
dc.contributor.authorGaulin, Elodieen
dc.contributor.authorGovers, Francineen
dc.contributor.authorGrenville-Briggs, Lauraen
dc.contributor.authorHorner, Neilen
dc.contributor.authorHostetler, Jessicaen
dc.contributor.authorJiang, Rays H.en
dc.contributor.authorJohnson, Justinen
dc.contributor.authorKrajaejun, Theerapongen
dc.contributor.authorLin, Hainingen
dc.contributor.authorMeijer, Harold J.en
dc.contributor.authorMoore, Barryen
dc.contributor.authorMorris, Paulen
dc.contributor.authorPhuntmart, Vipapornen
dc.contributor.authorPuiu, Danielaen
dc.contributor.authorShetty, Jyotien
dc.contributor.authorStajich, Jason E.en
dc.contributor.authorTripathy, Suchetaen
dc.contributor.authorWawra, Stephanen
dc.contributor.authorvan West, Pieteren
dc.contributor.authorWhitty, Brett R.en
dc.contributor.authorCoutinho, Pedro M.en
dc.contributor.authorHenrissat, Bernarden
dc.contributor.authorMartin, Franken
dc.contributor.authorThomas, Paul D.en
dc.contributor.authorTyler, Brett M.en
dc.contributor.authorDe Vries, Ronald P.en
dc.contributor.authorKamoun, Sophienen
dc.contributor.authorYandell, Marken
dc.contributor.authorTisserat, Neden
dc.contributor.authorBuell, C. Robinen
dc.date.accessioned2016-01-14T07:04:51Zen
dc.date.available2016-01-14T07:04:51Zen
dc.date.issued2010-07-13en
dc.date.updated2016-01-14T07:04:51Zen
dc.description.abstractBackground Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions, although, surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host-specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome, including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report of these in a genome outside the metazoans. Conclusions Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGenome Biology. 2010 Jul 13;11(7):R73en
dc.identifier.doihttps://doi.org/10.1186/gb-2010-11-7-r73en
dc.identifier.urihttp://hdl.handle.net/10919/64456en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderLévesque et al.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleGenome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoireen
dc.title.serialGenome Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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