Acid-base regulation during exercise in the horse

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dc.contributor.authorFerrante, Pamela L.en
dc.contributor.committeechairKronfeld, David S.en
dc.contributor.committeememberHerbein, Joseph H. Jr.en
dc.contributor.committeememberMeacham, Thomas N.en
dc.contributor.committeememberRankin, Janet L. Walbergen
dc.contributor.committeememberWilliams, Jay H.en
dc.contributor.departmentAnimal Scienceen
dc.date.accessioned2014-03-14T21:13:48Zen
dc.date.adate2008-06-06en
dc.date.available2014-03-14T21:13:48Zen
dc.date.issued1994-01-15en
dc.date.rdate2008-06-06en
dc.date.sdate2008-06-06en
dc.description.abstractEffects of fat adaptation and NaHC0₃ supplementation on acid-base homeostasis were quantitated during repeated sprint exercise in horses. Contribution of strong ions ([SID]), Pco₂, and weak electrolytes ([A<sub>tot</sub>]) to changes in plasma [H⁺] and the role of erythrocytes in acid-base balance were examined at rest and during exercise. Effects on plasma glucose and blood lactate [Lac⁻] concentrations due to sample handling were also assessed. During exercise, blood [Lac⁻] was higher when horses received NaHC0₃ compared to water prior to exercise (P=0.0024), and in fat adapted horses compared to horses fed a control diet (P=0.0240). Blood [Lac-] was higher in fat adapted horses given NaHC0₃ compared to other diet/treatment combinations (P=0.0276). Plasma [SID] was higher during exercise when horses were given NaHC0₃ compared to plain water (P=0.0054), which contributed to decreasing [H⁺] and increasing [HC0₃⁻] during exercise (P=0.0001). Plasma Pco₂ contributed less to increasing plasma [H⁺] during exercise in fat-adapted horses compared to horses fed the control diet (P=0.0282). Intraerythrocyte [SID] decreased (P=0.0160) and [Atod increased (P=0.0002) which contributed to increasing [H⁺] within the cell (P=0.0228).en
dc.description.degreePh. D.en
dc.format.extentix, 178 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06062008-164656en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06062008-164656/en
dc.identifier.urihttp://hdl.handle.net/10919/38287en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1994.F477.pdfen
dc.relation.isformatofOCLC# 30659012en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1994.F477en
dc.subject.lcshAcid-base equilibriumen
dc.subject.lcshBlood -- Analysisen
dc.subject.lcshHorses -- Exercise -- Physiological aspectsen
dc.titleAcid-base regulation during exercise in the horseen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineAnimal Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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