Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice
| dc.contributor.author | van der Heijden, Meike E. | en |
| dc.date.accessioned | 2024-12-02T15:22:15Z | en |
| dc.date.available | 2024-12-02T15:22:15Z | en |
| dc.date.issued | 2024-05-23 | en |
| dc.description.abstract | Evidence from clinical and preclinical studies has shown that the cerebellum contributes to cognitive functions, including social behaviors. Now that the cerebellum’s role in a wider range of behaviors has been confirmed, the question arises whether the cerebellum contributes to social behaviors via the same mechanisms with which it modulates movements. This review seeks to answer whether the cerebellum guides motor and social behaviors through identical pathways. It focuses on studies in which cerebellar cells, synapses, or genes are manipulated in a cell-type specific manner followed by testing of the effects on social and motor behaviors. These studies show that both anatomically restricted and cerebellar cortex-wide manipulations can lead to social impairments without abnormal motor control, and vice versa. These studies suggest that the cerebellum employs different cellular, synaptic, and molecular pathways for social and motor behaviors. Future studies warrant a focus on the diverging mechanisms by which the cerebellum contributes to a wide range of neural functions. | en |
| dc.description.version | Published version | en |
| dc.format.extent | Pages 1754-1767 | en |
| dc.format.extent | 14 page(s) | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | https://doi.org/10.1007/s12311-024-01706-w | en |
| dc.identifier.eissn | 1473-4230 | en |
| dc.identifier.issn | 1473-4222 | en |
| dc.identifier.issue | 5 | en |
| dc.identifier.orcid | van der Heijden, Meike [0000-0003-0801-8806] | en |
| dc.identifier.other | 10.1007/s12311-024-01706-w (PII) | en |
| dc.identifier.pmid | 38780757 | en |
| dc.identifier.uri | https://hdl.handle.net/10919/123672 | en |
| dc.identifier.volume | 23 | en |
| dc.language.iso | en | en |
| dc.publisher | Springer | en |
| dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/38780757 | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Cerebellum | en |
| dc.subject | Motor control | en |
| dc.subject | Social behaviors | en |
| dc.subject | Mice | en |
| dc.subject | Circuits | en |
| dc.subject | Genetic models | en |
| dc.subject.mesh | Cerebellum | en |
| dc.subject.mesh | Neural Pathways | en |
| dc.subject.mesh | Animals | en |
| dc.subject.mesh | Mice | en |
| dc.subject.mesh | Behavior, Animal | en |
| dc.subject.mesh | Motor Activity | en |
| dc.subject.mesh | Social Behavior | en |
| dc.title | Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice | en |
| dc.title.serial | Cerebellum | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |
| dc.type.other | Journal | en |
| dcterms.dateAccepted | 2024-05-17 | en |
| pubs.organisational-group | Virginia Tech | en |
| pubs.organisational-group | Virginia Tech/Science | en |
| pubs.organisational-group | Virginia Tech/Faculty of Health Sciences | en |
| pubs.organisational-group | Virginia Tech/All T&R Faculty | en |
| pubs.organisational-group | Virginia Tech/Science/COS T&R Faculty | en |
| pubs.organisational-group | Virginia Tech/Science/School of Neuroscience | en |