Cryptic Genetic Diversity within the Anopheles nili group of Malaria Vectors in the Equatorial Forest Area of Cameroon (Central Africa)

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dc.contributor.authorNdo, Cyrilleen
dc.contributor.authorSimard, Frédéricen
dc.contributor.authorKengne, Pierreen
dc.contributor.authorAwono-Ambene, Parfaiten
dc.contributor.authorMorlais, Isabelleen
dc.contributor.authorSharakhov, Igor V.en
dc.contributor.authorFontenille, Didieren
dc.contributor.authorAntonio-Nkondjio, Christopheen
dc.contributor.departmentEntomologyen
dc.date.accessioned2018-10-23T12:45:43Zen
dc.date.available2018-10-23T12:45:43Zen
dc.date.issued2013-03-14en
dc.description.abstractBackground The Anopheles nili group of mosquitoes includes important vectors of human malaria in equatorial forest and humid savannah regions of sub-Saharan Africa. However, it remains largely understudied, and data on its populations’ bionomics and genetic structure are crucially lacking. Here, we used a combination of nuclear (i.e. microsatellite and ribosomal DNA) and mitochondrial DNA markers to explore and compare the level of genetic polymorphism and divergence among populations and species of the group in the savannah and forested areas of Cameroon, Central Africa. Principal Findings All the markers provided support for the current classification within the An. nili group. However, they revealed high genetic heterogeneity within An. nili s.s. in deep equatorial forest environment. Nuclear markers showed the species to be composed of five highly divergent genetic lineages that differed by 1.8 to 12.9% of their Internal Transcribed Spacer 2 (ITS2) sequences, implying approximate divergence time of 0.82 to 5.86 million years. However, mitochondrial data only detected three major subdivisions, suggesting different evolutionary histories of the markers. Conclusions/Significance This study enlightened additional cryptic genetic diversity within An. nili s.s. in the deep equatorial forest environment of South Cameroon, reflecting a complex demographic history for this major vector of malaria in this environment. These preliminary results should be complemented by further studies which will shed light on the distribution, epidemiological importance and evolutionary history of this species group in the African rainforest, providing opportunities for in-depth comparative studies of local adaptation and speciation in major African malaria vectors.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0058862en
dc.identifier.eissn1932-6203en
dc.identifier.issue3en
dc.identifier.othere58862en
dc.identifier.pmid23516565en
dc.identifier.urihttp://hdl.handle.net/10919/85459en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleCryptic Genetic Diversity within the Anopheles nili group of Malaria Vectors in the Equatorial Forest Area of Cameroon (Central Africa)en
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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