Tolerability of Gemcitabine and Carboplatin Doublet Therapy in Cats with Carcinomas

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dc.contributor.authorMartinez-Ruzafa, I.en
dc.contributor.authorDominguez, Pedro A.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorSarbu, L.en
dc.contributor.authorNewman, R. G.en
dc.contributor.authorCadile, Casey D.en
dc.contributor.authorKitchell, Barbara E.en
dc.date.accessioned2016-11-15T20:50:29Zen
dc.date.available2016-11-15T20:50:29Zen
dc.date.issued2009-05-01en
dc.description.abstractBackground: This study was performed to determine the toxicity of gemcitabine-carboplatin doublet therapy in cats with carcinomas. Hypothesis: Gemcitabine and carboplatin are safe in tumor-bearing cats. Animals: Twenty cats with spontaneously occurring carcinomas. Methods: A cohort of 6 cats received gemcitabine (2 mg/kg IV) on days 1, 8, and 15 and carboplatin (10 mg/kg IV) immediately after gemcitabine on day 1 of a 21-day cycle. A 2nd cohort of 14 cats received carboplatin 4 hours after gemcitabine on day 1 and gemcitabine on day 8 but not day 15. The cycles were repeated every 21 days. Results: Cats in the 1st cohort received a median of 3.75 cycles per animal (range, 1–6). Two cats (33.3%) developed grade 3 or 4 neutropenia, 1 (16.7%) grade 4 thrombocytopenia, and 1 (16.7%) grade 3 gastrointestinal toxicity. Gemcitabine dose reductions and treatment delays occurred in 1 and 4 cats, respectively. Cats in the 2nd cohort received a median of 2 cycles per animal (range, 0.5–10). Two cats (14.3%) had grade 3 or 4 neutropenia and 1 (7.1%) had grade 3 and 4 gastrointestinal toxicity. One cat required gemcitabine dose reduction and 6 had treatment delays. In the 2nd cohort, of 11 cats with measurable tumors, there was 1 complete response (pancreatic carcinoma) and 1 partial response (squamous cell carcinoma, receiving concurrent nonsteroidal anti-inflammatory drugs). Conclusions and Clinical Importance: Gemcitabine-carboplatin combination appears moderately well tolerated in tumor-bearing cats. Minimal patient benefit suggests that alternative schedules or combinations of gemcitabine with other agents should be explored.en
dc.description.versionPublished versionen
dc.format.extent570 - 577 (8) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/j.1939-1676.2009.0279.xen
dc.identifier.issn0891-6640en
dc.identifier.issue3en
dc.identifier.urihttp://hdl.handle.net/10919/73462en
dc.identifier.volume23en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266112300021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectChemotherapeuticsen
dc.subjectChemotherapyen
dc.subjectDrug interactionsen
dc.subjectOncology treatmenten
dc.subjectCOOPERATIVE ONCOLOGY GROUPen
dc.subjectCANCER CELL-LINESen
dc.subjectPHASE-IIen
dc.subjectIN-VITROen
dc.subjectCLINICAL-EVALUATIONen
dc.subjectPRIMARY METABOLITEen
dc.subjectPANCREATIC-CANCERen
dc.subjectMALIGNANT-TUMORSen
dc.subjectLUNG-CANCERen
dc.subjectCISPLATINen
dc.titleTolerability of Gemcitabine and Carboplatin Doublet Therapy in Cats with Carcinomasen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
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