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The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota

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dc.contributor.authorAnderson, Iain J.en
dc.contributor.authorDharmarajan, Lakshmien
dc.contributor.authorRodriguez, Jasonen
dc.contributor.authorHooper, Seanen
dc.contributor.authorPorat, Irisen
dc.contributor.authorUlrich, Luke E.en
dc.contributor.authorElkins, James G.en
dc.contributor.authorMavromatis, Kostasen
dc.contributor.authorSun, Huien
dc.contributor.authorLand, Miriamen
dc.contributor.authorLapidus, Allaen
dc.contributor.authorLucas, Susanen
dc.contributor.authorBarry, Kerrie W.en
dc.contributor.authorHuber, Haralden
dc.contributor.authorZhulin, Igor B.en
dc.contributor.authorWhitman, William B.en
dc.contributor.authorMukhopadhyay, Biswarupen
dc.contributor.authorWoese, Carlen
dc.contributor.authorBristow, Jamesen
dc.contributor.authorKyrpides, Nikos C.en
dc.contributor.departmentBiochemistryen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2012-08-24T12:04:28Zen
dc.date.available2012-08-24T12:04:28Zen
dc.date.issued2009-04-02en
dc.date.updated2012-08-24T12:04:28Zen
dc.description.abstractBackground Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides an opportunity for comparative analysis of the three genomes. Results The 1.57 Mbp genome of the hyperthermophilic crenarchaeote Staphylothermus marinus has been completely sequenced. The main energy generating pathways likely involve 2-oxoacid:ferredoxin oxidoreductases and ADP-forming acetyl-CoA synthases. S. marinus possesses several enzymes not present in other crenarchaeotes including a sodium ion-translocating decarboxylase likely to be involved in amino acid degradation. S. marinus lacks sulfur-reducing enzymes present in the other two sulfur-reducing crenarchaeotes that have been sequenced - Thermofilum pendens and Hyperthermus butylicus. Instead it has three operons similar to the mbh and mbx operons of Pyrococcus furiosus, which may play a role in sulfur reduction and/or hydrogen production. The two marine organisms, S. marinus and H. butylicus, possess more sodium-dependent transporters than T. pendens and use symporters for potassium uptake while T. pendens uses an ATP-dependent potassium transporter. T. pendens has adapted to a nutrient-rich environment while H. butylicus is adapted to a nutrient-poor environment, and S. marinus lies between these two extremes. Conclusion The three heterotrophic sulfur-reducing crenarchaeotes have adapted to their habitats, terrestrial vs. marine, via their transporter content, and they have also adapted to environments with differing levels of nutrients. Despite the fact that they all use sulfur as an electron acceptor, they are likely to have different pathways for sulfur reduction.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBMC Genomics. 2009 Apr 02;10(1):145en
dc.identifier.doihttps://doi.org/10.1186/1471-2164-10-145en
dc.identifier.urihttp://hdl.handle.net/10919/18899en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderIain J Anderson et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeotaen
dc.title.serialBMC Genomicsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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