Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

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dc.contributor.authorGao, Fengen
dc.contributor.authorChen, Manyuen
dc.contributor.authorYu, Jianfengen
dc.contributor.authorXu, Luen
dc.contributor.authorYu, Lishaen
dc.contributor.authorJiang, Honglinen
dc.contributor.authorGu, Zhiliangen
dc.date.accessioned2022-08-02T14:57:40Zen
dc.date.available2022-08-02T14:57:40Zen
dc.date.issued2022-02en
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is the most common liver metabolic disease in the world. In this study we investigated the effect of tetrahydrocurcumin (THC), a potent antioxidant, on NAFLD. We found that THC significantly reduced the body weight, serum and liver lipids, serum malondialdehyde (MDA) and fasting blood glucose (FBG) of male NAFLD mice induced by feeding a high-fat diet (HFD) for 8 weeks. A RNA-seq analysis revealed that THC also affected the expression of many genes involved in lipid metabolism in the liver of NAFLD mice, including increasing the mRNA expression of CYP51 and FOXQ1. Moreover, THC significantly reduced sodium oleate-induced lipid accumulation, activated the NRF2 pathway, and up-regulated the mRNA expression of FGF21 in HepG2 cells. Overall, our study showed that THC can improve the antioxidant capacity of liver, which suggests that dietary THC may be used to treat NAFLD.en
dc.description.notesAcknowledgements This study was supported by National Natural Science Foundation of China (31772593) and Natural Science Foundation of Jiangsu Province (BK20191476) .en
dc.description.sponsorshipNational Natural Science Foundation of China [31772593]; Natural Science Foundation of Jiangsu Province [BK20191476]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.jff.2022.104957en
dc.identifier.eissn2214-9414en
dc.identifier.issn1756-4646en
dc.identifier.other104957en
dc.identifier.urihttp://hdl.handle.net/10919/111426en
dc.identifier.volume89en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectTetrahydrocurcuminen
dc.subjectNon-alcoholic fatty liver diseaseen
dc.subjectTranscriptomeen
dc.subjectAntioxidanten
dc.subjectNRF2en
dc.titleTetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasisen
dc.title.serialJournal of Functional Foodsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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