Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity

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dc.contributor.authorYang, Lingyuen
dc.contributor.authorLiu, Shuyunen
dc.contributor.authorDing, Jinmeien
dc.contributor.authorDai, Ronghuaen
dc.contributor.authorHe, Chuanen
dc.contributor.authorXu, Keen
dc.contributor.authorHonaker, Christa F.en
dc.contributor.authorZhang, Yanen
dc.contributor.authorSiegel, Paul B.en
dc.contributor.authorMeng, Heen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2019-03-14T14:19:49Zen
dc.date.available2019-03-14T14:19:49Zen
dc.date.issued2017-07-04en
dc.description.abstractTo explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2017.01243en
dc.identifier.issn1664-302Xen
dc.identifier.pmid28725219en
dc.identifier.urihttp://hdl.handle.net/10919/88443en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleGut Microbiota Co-microevolution with Selection for Host Humoral Immunityen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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