Magnetization transfer and diffusion tensor imaging in dogs with intervertebral disk herniation

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dc.contributor.authorShinn, Richard L.en
dc.contributor.authorPancotto, Theresa E.en
dc.contributor.authorStadler, Krystina L.en
dc.contributor.authorWerre, Stephen R.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.departmentSmall Animal Clinical Sciencesen
dc.date.accessioned2021-09-02T14:48:34Zen
dc.date.available2021-09-02T14:48:34Zen
dc.date.issued2020-10-02en
dc.date.updated2021-09-02T14:48:31Zen
dc.description.abstractBackground: Quantitative magnetic resonance imaging (QMRI) techniques of magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) provide microstructural information about the spinal cord. Objective: Compare neurologic grades using the modified Frankel scale with MTR and DTI measurements in dogs with thoracolumbar intervertebral disk herniation (IVDH). Animals: Fifty-one dogs with thoracolumbar IVDH. Methods: Prospective cohort study. Quantitative MRI measurements of the spinal cord were obtained at the region of compression. A linear regression generalized estimating equations model was used to compare QMRI measurements between different neurological grades after adjusting for age, weight, duration of clinical signs, and lesion location. Results: Grade 5 (.79 × 10−3 mm2/s [median],.43−.91 [range]) and axial (1.47 × 10−3 mm2/s,.58−1.8) diffusivity were lower compared to grades 2 (1.003,.68−1.36; P =.02 and 1.81 × 10−3 mm2/s, 1.36−2.12; P <.001, respectively) and 3 (1.07 × 10−3 mm2/s,.77−1.5; P =.04 and 1.92 × 10−3 mm2/s, 1.83−2.37; P <.001, respectively). Compared to dogs with acute myelopathy, chronic myelopathy was associated with higher mean (1.02 × 10−3 mm2/s,.77−1.36 vs.83 × 10−3 mm2/s,.64−1.5; P =.03) and radial diffusivity (.75 × 10−3 mm2/s,.38−1.04 vs.44 × 10−3 mm2/s,.22−1.01; P =.008) and lower MTR (46.76, 31.8−56.43 vs. 54.4, 45.2−62.27; P =.004) and fractional anisotropy (.58,.4−0.75 vs.7,.46−.85; P =.02). Fractional anisotropy was lower in dogs with a T2-weighted intramedullary hyperintensity compared to those without (.7,.45−.85 vs.54,.4−.8; P =.01). Conclusion and Clinical Relevance: Mean diffusivity and AD could serve as surrogates of severity of spinal cord injury and are complementary to the clinical exam in dogs with thoracolumbar IVDH.en
dc.description.versionPublished versionen
dc.format.extentPages 2536-2544en
dc.format.extent9 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15899en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue6en
dc.identifier.orcidWerre, Stephen [0000-0003-1638-6705]en
dc.identifier.pmid33006411en
dc.identifier.urihttp://hdl.handle.net/10919/104901en
dc.identifier.volume34en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000574170100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectVeterinary Sciencesen
dc.subjectaxial diffusivityen
dc.subjectfractional anisotropyen
dc.subjectintervertebral disk diseaseen
dc.subjectmagnetic resonance imagingen
dc.subjectmagnetization transfer ratioen
dc.subjectmean diffusivityen
dc.subjectradial diffusivityen
dc.subjectspinal cord injuryen
dc.subjectSPINAL-CORD-INJURYen
dc.subjectPAIN PERCEPTIONen
dc.subjectMOTOR FUNCTIONen
dc.subjectRECOVERYen
dc.subjectBRAINen
dc.subjectPARAPLEGIAen
dc.subjectPARAMETERSen
dc.subjectSEVERITYen
dc.subjectMRIen
dc.subjectVeterinary Sciencesen
dc.subject0707 Veterinary Sciencesen
dc.subject.meshAnimalsen
dc.subject.meshDogsen
dc.subject.meshDog Diseasesen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshProspective Studiesen
dc.subject.meshDiffusion Tensor Imagingen
dc.subject.meshIntervertebral Disc Displacementen
dc.subject.meshIntervertebral Discen
dc.subject.meshIntervertebral Disc Degenerationen
dc.titleMagnetization transfer and diffusion tensor imaging in dogs with intervertebral disk herniationen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2020-08-20en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen

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