Assessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Model

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dc.contributor.authorPoranki, D.en
dc.contributor.authorGoodwin, C.en
dc.contributor.authorVan Dyke, M.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2017-03-01T16:03:45Zen
dc.date.available2017-03-01T16:03:45Zen
dc.date.issued2016-01-01en
dc.description.abstractPartial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD). Digital images of each wound were taken for area measurements immediately prior to cleaning and dressing changes. Wound tissue was collected and assessed histologically at several time points. Wound area showed a significant difference between hydrogels and SSD groups, and rates of reepithelialization at early time points showed an increase when keratin treatment was used compared to both collagen and SSD. A linear regression model predicted a time to wound closure of approximately 25 days for keratin hydrogel while SSD treatment required 35 days. There appeared to be no measurable differences between the modified and unmodified formulations of keratin hydrogels.en
dc.description.versionPublished versionen
dc.format.extent? - ? (10) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationD. Poranki, C. Goodwin, and M. Van Dyke, “Assessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Model,” BioMed Research International, vol. 2016, Article ID 1803912, 10 pages, 2016. doi:10.1155/2016/1803912en
dc.identifier.doihttps://doi.org/10.1155/2016/1803912en
dc.identifier.issn2314-6133en
dc.identifier.urihttp://hdl.handle.net/10919/75206en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000389929700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2016 D. Poranki et al.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiotechnology & Applied Microbiologyen
dc.subjectMedicine, Research & Experimentalen
dc.subjectResearch & Experimental Medicineen
dc.subjectTHROMBIN PEPTIDEen
dc.subjectSILVER SULFADIAZINEen
dc.subjectENDOTHELIAL-CELLSen
dc.subjectTHERMAL-STRESSen
dc.subjectIN-VITROen
dc.subjectTP508en
dc.subjectPATHWAYen
dc.subjectHAIRen
dc.titleAssessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Modelen
dc.title.serialBioMed Research Internationalen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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