Demographic feedbacks during evolutionary rescue can slow or speed adaptive evolution

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dc.contributor.authorDraghi, Jeremy A.en
dc.contributor.authorMcGlothlin, Joel W.en
dc.contributor.authorKindsvater, Holly K.en
dc.date.accessioned2025-01-27T19:47:37Zen
dc.date.available2025-01-27T19:47:37Zen
dc.date.issued2024-02-14en
dc.description.abstractPopulations declining toward extinction can persist via genetic adaptation in a process called evolutionary rescue. Predicting evolutionary rescue has applications ranging from conservation biology to medicine, but requires understanding and integrating the multiple effects of a stressful environmental change on population processes. Here we derive a simple expression for how generation time, a key determinant of the rate of evolution, varies with population size during evolutionary rescue. Change in generation time is quantitatively predicted by comparing how intraspecific competition and the source of maladaptation each affect the rates of births and deaths in the population. Depending on the difference between two parameters quantifying these effects, the model predicts that populations may experience substantial changes in their rate of adaptation in both positive and negative directions, or adapt consistently despite severe stress. These predictions were then tested by comparison to the results of individual-based simulations of evolutionary rescue, which validated that the tolerable rate of environmental change varied considerably as described by analytical results. We discuss how these results inform efforts to understand wildlife disease and adaptation to climate change, evolution in managed populations and treatment resistance in pathogens.en
dc.description.versionPublished versionen
dc.format.extent10 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 20231553 (Article number)en
dc.identifier.doihttps://doi.org/10.1098/rspb.2023.1553en
dc.identifier.eissn1471-2954en
dc.identifier.issn0962-8452en
dc.identifier.issue20231553en
dc.identifier.orcidMcGlothlin, Joel [0000-0003-3645-6264]en
dc.identifier.orcidKindsvater, Holly [0000-0001-7580-4095]en
dc.identifier.pmid38351805en
dc.identifier.urihttps://hdl.handle.net/10919/124403en
dc.identifier.volume291en
dc.language.isoenen
dc.publisherThe Royal Societyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/38351805en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectevolutionary rescueen
dc.subjectdemographyen
dc.subjectadaptationen
dc.subjectevolutionary theoryen
dc.subject.meshPopulation Densityen
dc.subject.meshAdaptation, Physiologicalen
dc.subject.meshFeedbacken
dc.subject.meshBiological Evolutionen
dc.titleDemographic feedbacks during evolutionary rescue can slow or speed adaptive evolutionen
dc.title.serialProceedings of the Royal Society B: Biological Sciencesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2024-01-16en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Natural Resources & Environmenten
pubs.organisational-groupVirginia Tech/Natural Resources & Environment/Fish and Wildlife Conservationen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Science/Biological Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Natural Resources & Environment/CNRE T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen

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