A Tumor Suppressor-Dependent Inhibitor of Angiogenesis Is Immunologically and Functionally Indistinguishable From a Fragment of Thrombospondin

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dc.contributor.authorGood, Deborah J.en
dc.contributor.authorPolverini, Peter J.en
dc.contributor.authorRastinejad, Farzanen
dc.contributor.authorLe Beau, Michelle M.en
dc.contributor.authorLemons, Richard S.en
dc.contributor.authorFrazier, William A.en
dc.contributor.authorBouck, Noel P.en
dc.date.accessioned2025-01-10T19:57:50Zen
dc.date.available2025-01-10T19:57:50Zen
dc.date.issued1990-09en
dc.description.abstractA secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in hamster cells has been found to be similar to a fragment of the platelet and matrix protein thrombospondin. The two proteins were biochemically similar and immunologically crossreactive and could substitute for one another in two functional assays. Human thrombospondin inhibited neovascularization in vivo and endothelial cell migration in vitro, as does the hamster protein, gp140. gp140 sensitized smooth muscle cells to stimulation by epidermal growth factor, as does human thrombospondin. The thrombospondin gene has been localized on human chromosome 15. These results demonstrate a function for the ubiquitous adhesive glycoprotein thrombospondin that is likely to be important in the normal physiological down-regulation of neovascularization. In addition, they raise the possibility that thrombospondin may be one of a number of target molecules through which a tumor suppressor gene could act to restrain tumor growth.en
dc.description.versionPublished versionen
dc.format.extentPages 6624-6628en
dc.format.extent5 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1073/pnas.87.17.6624en
dc.identifier.eissn1091-6490en
dc.identifier.issn0027-8424en
dc.identifier.issue17en
dc.identifier.orcidGood, Deborah [0000-0003-0136-0975]en
dc.identifier.pmid1697685en
dc.identifier.urihttps://hdl.handle.net/10919/124149en
dc.identifier.volume87en
dc.language.isoenen
dc.publisherNational Academy of Sciencesen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/1697685en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.meshBlood Plateletsen
dc.subject.meshCell Lineen
dc.subject.meshChromosomes, Human, Pair 15en
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshNeovascularization, Pathologicen
dc.subject.meshGlycoproteinsen
dc.subject.meshMembrane Glycoproteinsen
dc.subject.meshThrombospondinsen
dc.subject.meshSuppression, Geneticen
dc.subject.meshAmino Acid Sequenceen
dc.subject.meshSequence Homology, Nucleic Aciden
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshCricetinaeen
dc.titleA Tumor Suppressor-Dependent Inhibitor of Angiogenesis Is Immunologically and Functionally Indistinguishable From a Fragment of Thrombospondinen
dc.title.serialProceedings of the National Academy of Sciences of the United States of Americaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciencesen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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