Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes

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dc.contributor.authorBaugh, Mary Elizabethen
dc.contributor.authorSteele, Cortney N.en
dc.contributor.authorAngiletta, Christopher J.en
dc.contributor.authorMitchell, Cassie M.en
dc.contributor.authorNeilson, Andrew P.en
dc.contributor.authorDavy, Brenda M.en
dc.contributor.authorHulver, Matthew W.en
dc.contributor.authorDavy, Kevin P.en
dc.contributor.departmentFood Science and Technologyen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2018-06-25T12:25:04Zen
dc.date.available2018-06-25T12:25:04Zen
dc.date.issued2018-06-20en
dc.date.updated2018-06-25T07:44:59Zen
dc.description.abstractTrimethylamine <i>N</i>-oxide (TMAO) is associated with type 2 diabetes (T2DM) and increased risk of adverse cardiovascular events. Prebiotic supplementation has been purported to reduce TMAO production, but whether prebiotics reduce fasting or postprandial TMAO levels is unclear. Sedentary, overweight/obese adults at risk for T2DM (<i>n</i> = 18) were randomized to consume a standardized diet (55% carbohydrate, 30% fat) with 10 g/day of either an inulin supplement or maltodextrin placebo for 6 weeks. Blood samples were obtained in the fasting state and hourly during a 4-h high-fat challenge meal (820 kcal; 25% carbohydrate, 63% fat; 317.4 mg choline, 62.5 mg betaine, 8.1 mg <span>l</span>-carnitine) before and after the diet. Plasma TMAO and trimethylamine (TMA) moieties (choline, <span>l</span>-carnitine, betaine, and &gamma;-butyrobetaine) were measured using isocratic ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). There were no differences in fasting or postprandial TMAO or TMA moieties between the inulin and placebo groups at baseline (all <i>p</i> &gt; 0.05). There were no significant changes in fasting or postprandial plasma TMAO or TMA moiety concentrations following inulin or placebo. These findings suggest that inulin supplementation for 6 weeks did not reduce fasting or postprandial TMAO in individuals at risk for T2DM. Future studies are needed to identify efficacious interventions that reduce plasma TMAO concentrations.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBaugh, M.E.; Steele, C.N.; Angiletta, C.J.; Mitchell, C.M.; Neilson, A.P.; Davy, B.M.; Hulver, M.W.; Davy, K.P. Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes. Nutrients 2018, 10, 793.en
dc.identifier.doihttps://doi.org/10.3390/nu10060793en
dc.identifier.urihttp://hdl.handle.net/10919/83726en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectprediabetesen
dc.subjectprebioticen
dc.subjectmetaboliteen
dc.subjectcardiovascularen
dc.subjectmetabolismen
dc.titleInulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetesen
dc.title.serialNutrientsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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