Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects

Simple item page
dc.contributor.authorPrabhu, Raj K.en
dc.contributor.authorBegonia, Mark T.en
dc.contributor.authorWhittington, Wilburn R.en
dc.contributor.authorMurphy, Michael A.en
dc.contributor.authorMao, Yuxiongen
dc.contributor.authorLiao, Junen
dc.contributor.authorWilliams, Lakiesha N.en
dc.contributor.authorHorstemeyer, Mark F.en
dc.contributor.authorSheng, Jianpingen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2019-05-17T14:43:40Zen
dc.date.available2019-05-17T14:43:40Zen
dc.date.issued2019-05-07en
dc.date.updated2019-05-16T20:02:06Zen
dc.description.abstractDesigning protective systems for the human head—and, hence, the brain—requires understanding the brain’s microstructural response to mechanical insults. We present the behavior of wet and dry porcine brain undergoing quasi-static and high strain rate mechanical deformations to unravel the effect of hydration on the brain’s biomechanics. Here, native ‘wet’ brain samples contained ~80% (mass/mass) water content and ‘dry’ brain samples contained ~0% (mass/mass) water content. First, the wet brain incurred a large initial peak stress that was not exhibited by the dry brain. Second, stress levels for the dry brain were greater than the wet brain. Third, the dry brain stress–strain behavior was characteristic of ductile materials with a yield point and work hardening; however, the wet brain showed a typical concave inflection that is often manifested by polymers. Finally, finite element analysis (FEA) of the brain’s high strain rate response for samples with various proportions of water and dry brain showed that water played a major role in the initial hardening trend. Therefore, hydration level plays a key role in brain tissue micromechanics, and the incorporation of this hydration effect on the brain’s mechanical response in simulated injury scenarios or virtual human-centric protective headgear design is essential.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPrabhu, R.K.; Begonia, M.T.; Whittington, W.R.; Murphy, M.A.; Mao, Y.; Liao, J.; Williams, L.N.; Horstemeyer, M.F.; Sheng, J. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects. Bioengineering 2019, 6, 40.en
dc.identifier.doihttps://doi.org/10.3390/bioengineering6020040en
dc.identifier.urihttp://hdl.handle.net/10919/89553en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectporcine brainen
dc.subjectmechanical behavioren
dc.subjecthydration effectsen
dc.subjectSplit-Hopkinson pressure baren
dc.subjectmicromechanicsen
dc.subjectFinite element methoden
dc.titleCompressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effectsen
dc.title.serialBioengineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
bioengineering-06-00040.pdf
Size:
6.82 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Biomedical Engineering and Mechanics