Investigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidism

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dc.contributor.authorMorre, Wendy A.en
dc.contributor.authorPanciera, David L.en
dc.contributor.authorDaniel, Gregory B.en
dc.contributor.authorMonroe, William E.en
dc.contributor.authorWerre, Stephen R.en
dc.date.accessioned2021-10-19T12:34:04Zen
dc.date.available2021-10-19T12:34:04Zen
dc.date.issued2018-11-01en
dc.date.updated2021-10-19T12:34:02Zen
dc.description.abstractBackground: Radioiodine is the treatment of choice for hyperthyroidism in cats. The ideal method of dose determination of radioiodine remains controversial. Objective: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of hyperthyroidism. Animals: Fifty-seven and 23 client-owned hyperthyroid cats in the variable and fixed dose groups, respectively. Methods: Cats with a percent dose uptake using 99mTc-pertechnetate uptake on thyroid scintigraphy <5%, 5%-10%, and >10% were to receive 3, 3.5, or 4.5 millicuries (mCi) of radioiodine, respectively, administered SC. Radioiodine dose was adjusted according to thyroid gland size as determined by the thyroid:salivary size ratio and categorized as <5:1, 5-10:1, and >10:1. If the thyroid size fell into a higher dosing category than the percent dose uptake, the dose was increased accordingly. Cats in the fixed dose group received 4.5 mCi. Six months after treatment, cats were determined to be euthyroid, hypothyroid, or hyperthyroid based on serum thyroxine and thyroid stimulating hormone concentrations. Results: No difference in outcome was found between the variable and fixed dose treatment groups. Euthyroidism, hypothyroidism, and persistent hyperthyroidism developed in 61, 30, and 9% of cats in the fixed dose group compared to 58, 26, and 16%, respectively, in the variable dose group. Conclusions: A variable dosing method of radioiodine based on percent dose uptake primarily and thyroid gland size secondarily did not improve outcome compared to a standard fixed dose method.en
dc.description.versionPublished versionen
dc.format.extentPages 1856-1863en
dc.format.extent8 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15296en
dc.identifier.eissn1939-1676en
dc.identifier.issn1939-1676en
dc.identifier.issue6en
dc.identifier.orcidDaniel, Gregory [0000-0002-7313-7425]en
dc.identifier.orcidWerre, Stephen [0000-0003-1638-6705]en
dc.identifier.pmid30328158en
dc.identifier.urihttp://hdl.handle.net/10919/105416en
dc.identifier.volume32en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451827600006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectVeterinary Sciencesen
dc.subjectfelineen
dc.subjecthyperthyroiden
dc.subjectradioiodineen
dc.subjectscintigraphyen
dc.subjectQUANTITATIVE THYROID SCINTIGRAPHYen
dc.subjectSERUM THYROXINEen
dc.subjectCATSen
dc.subjectPERTECHNETATEen
dc.subjectHYPOTHYROIDISMen
dc.subjectASSOCIATIONen
dc.subjectDIAGNOSISen
dc.subjectAZOTEMIAen
dc.subjectVeterinary Sciencesen
dc.subject0707 Veterinary Sciencesen
dc.subject.meshAnimalsen
dc.subject.meshCatsen
dc.subject.meshHyperthyroidismen
dc.subject.meshCat Diseasesen
dc.subject.meshIodine Radioisotopesen
dc.subject.meshTreatment Outcomeen
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.subject.meshDrug Dosage Calculationsen
dc.titleInvestigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidismen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2018-07-17en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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