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Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors

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dc.contributor.authorRuger, Lauren N.en
dc.contributor.authorHay, Alayna N.en
dc.contributor.authorGannon, Jessica M.en
dc.contributor.authorSheppard, Hannah O.en
dc.contributor.authorCoutermarsh-Ott, Sheryl L.en
dc.contributor.authorDaniel, Gregory B.en
dc.contributor.authorKierski, Katharine R.en
dc.contributor.authorCiepluch, Brittany J.en
dc.contributor.authorVlaisavljevich, Elien
dc.contributor.authorTuohy, Joanne L.en
dc.date.accessioned2023-04-10T17:46:36Zen
dc.date.available2023-04-10T17:46:36Zen
dc.date.issued2023-01en
dc.description.abstractObjective: Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely non-invasive and non-thermal ablation technique, histotripsy has the potential to significantly improve the standard of care for patients with primary bone tumors. Introduction: Standard of care treatment for primary appendicular OS involves surgical resection via either limb amputation or limb-salvage surgery for suitable candidates. Biological similarities between canine and human OS make the dog an informative comparative oncology research model to advance treatment options for primary OS. Evaluating histotripsy for ablating spontaneous canine primary OS will build a foundation upon which histotripsy can be translated clinically into a standard of care therapy for canine and human OS. Methods: Five dogs with suspected spontaneous OS were treated with a 500 kHz histotripsy system guided by real-time ultrasound image guidance. Spherical ablation volumes within each tumor (1.25-3 cm in diameter) were treated with single cycle histotripsy pulses applied at a pulse repetition frequency of 500 Hz and a dose of 500 pulses/point. Results: Tumor ablation was successfully identified grossly and histologically within the targeted treatment regions of all subjects. Histotripsy treatments were well-tolerated amongst all patients with no significant clinical adverse effects. Conclusion & Significance: Histotripsy safely and effectively ablated the targeted treatment volumes in all subjects, demonstrating its potential to serve as a non-invasive treatment modality for primary bone tumors.en
dc.description.notesThis work was supported in part by the AmericanKennel Club Canine Health Foundation under Grant 02773, in part bythe Focused Ultrasound Foundation Veterinary Program under Project FUSF-RAP-823R1, and in part by The National Institutes of Health under Project 1R21EB030182-01. The work of Lauren N. Ruger wassupported by the Virginia Tech Institute for Critical Technology andApplied Science Doctoral Scholars Program.en
dc.description.sponsorshipAmericanKennel Club Canine Health Foundation [02773]; Focused Ultrasound Foundation Veterinary Program [FUSF-RAP-823R1]; National Institutes of Health [1R21EB030182-01]; Virginia Tech Institute for Critical Technology and Applied Science Doctoral Scholars Programen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1109/TBME.2022.3191069en
dc.identifier.eissn1558-2531en
dc.identifier.issue1en
dc.identifier.pmid35834467en
dc.identifier.urihttp://hdl.handle.net/10919/114454en
dc.identifier.volume70en
dc.language.isoenen
dc.publisherIEEEen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAblationen
dc.subjectbone tumorsen
dc.subjectcanineen
dc.subjectfocused ultrasounden
dc.subjecthistotripsyen
dc.subjectosteosarcomaen
dc.titleHistotripsy Ablation of Spontaneously Occurring Canine Bone Tumorsen
dc.title.serialIEEE Transactions on Biomedical Engineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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