dc.contributor.author	Shabrokh, Elika	en
dc.contributor.committeechair	Frisard, Madlyn I.	en
dc.contributor.committeemember	Davy, Kevin P.	en
dc.contributor.committeemember	Helm, Richard F.	en
dc.contributor.committeemember	Hulver, Matthew W.	en
dc.contributor.department	Human Nutrition, Foods, and Exercise	en
dc.date.accessioned	2014-04-30T08:00:21Z	en
dc.date.available	2014-04-30T08:00:21Z	en
dc.date.issued	2014-04-29	en
dc.description.abstract	Sporadic Inclusion Body Myositis (sIBM) is an inflammatory muscle disease that strikes individuals at random and accounts for approximately 1/3 of all idiopathic inflammatory myopathies. It is characterized by progressive weakness of distal and proximal muscles and is the most common muscle disorder in individuals over 50 years of age. Currently, there is no known cause, cure, or enduring treatment for sIBM, although a number of theories as to its cause have been proposed. One theory proposes that activation of the inflammatory/ immune response is the primary trigger resulting in muscle degeneration and protein abnormalities, while an alternative theory suggests that sIBM is a degenerative muscle disease with abnormal pathogenic protein accumulation, in particular Abeta, being a primary cause that triggers an inflammatory/ immune response. Mitochondrial abnormalities have been observed in skeletal muscle from patients diagnosed with the disease, however the role of the mitochondria in disease pathology is still unclear. The aim of this dissertation was to evaluate: 1) the role of the mitochondria in the development of sIBM and 2) the role of amyloid beta on mitochondrial function in skeletal muscle. A better understanding of the role of the mitochondria in the development of sIBM may help to identify novel prevention and/ or treatment strategies.	en
dc.description.degree	Ph. D.	en
dc.format.medium	ETD	en
dc.identifier.other	vt_gsexam:2627	en
dc.identifier.uri	http://hdl.handle.net/10919/47782	en
dc.publisher	Virginia Tech	en
dc.rights	In Copyright	en
dc.rights.uri	http://rightsstatements.org/vocab/InC/1.0/	en
dc.subject	Amyloid beta	en
dc.subject	Inclusion Body Myositis	en
dc.subject	Mitochondria	en
dc.title	Mitochondrial Biology in Sporadic Inclusion Body Myositis	en
dc.type	Dissertation	en
thesis.degree.discipline	Human Nutrition, Foods, and Exercise	en
thesis.degree.grantor	Virginia Polytechnic Institute and State University	en
thesis.degree.level	doctoral	en
thesis.degree.name	Ph. D.	en

Mitochondrial Biology in Sporadic Inclusion Body Myositis

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