Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator

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dc.contributor.authorZheng, Louise D.en
dc.contributor.authorLinarelli, Leah E.en
dc.contributor.authorBrooke, Josephen
dc.contributor.authorSmith, Cayleen M.en
dc.contributor.authorWall, Sarah S.en
dc.contributor.authorGreenawald, Mark H.en
dc.contributor.authorSeidel, Richard W.en
dc.contributor.authorEstabrooks, Paul A.en
dc.contributor.authorAlmeida, Fabio A.en
dc.contributor.authorCheng, Zhiyongen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-07-20T18:53:02Zen
dc.date.available2017-07-20T18:53:02Zen
dc.date.issued2016-04-26en
dc.description.abstractType 2 diabetes (T2D) is characterized by mitochondrial derangement and oxidative stress. With no known cure for T2D, it is critical to identify mitochondrial biomarkers for early diagnosis of prediabetes and disease prevention. Here we examined 87 participants on the diagnosis power of fasting glucose (FG) and hemoglobin A1c levels and investigated their interactions with mitochondrial DNA methylation. FG and A1c led to discordant diagnostic results irrespective of increased body mass index (BMI), underscoring the need of new biomarkers for prediabetes diagnosis. Mitochondrial DNA methylation levels were not correlated with late-stage (impaired FG or A1c) but significantly with early-stage (impaired insulin sensitivity) events. Quartiles of BMI suggested that mitochondrial DNA methylation increased drastically from Q1 (20 < BMI < 24.9, lean) to Q2 (30 < BMI < 34.9, obese), but marginally from Q2 to Q3 (35 < BMI < 39.9, severely obese) and from Q3 to Q4 (BMI > 40, morbidly obese). A significant change was also observed from Q1 to Q2 inHOMA insulin sensitivity but not in A1c or FG. Thus, mitochondrial epigenetic changes link to increased diabetes risk and the indicator of early-stage prediabetes. Further larger-scale studies to examine the potential of mitochondrial epigenetic marker in prediabetes diagnosis will be of critical importance for T2D prevention.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLouise D. Zheng, Leah E. Linarelli, Joseph Brooke, Cayleen Smith, Sarah S. Wall, Mark H. Greenawald, Richard W. Seidel, Paul A. Estabrooks, Fabio A. Almeida, Zhiyong Cheng, "Mitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicator", Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 5290638, 10 pages, 2016. https://doi.org/10.1155/2016/5290638en
dc.identifier.doihttps://doi.org/10.1155/2016/5290638en
dc.identifier.urihttp://hdl.handle.net/10919/78379en
dc.identifier.volume2016en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMitochondrial Epigenetic Changes Link to Increased Diabetes Risk and Early-Stage Prediabetes Indicatoren
dc.title.serialOxidative Medicine and Cellular Longevityen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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