Cardiovascular aging: from cellular and molecular changes to therapeutic interventions

Simple item page
dc.contributor.authorVakka, Angelikien
dc.contributor.authorWarren, Junco S.en
dc.contributor.authorDrosatos, Konstantinosen
dc.date.accessioned2024-02-05T13:16:33Zen
dc.date.available2024-02-05T13:16:33Zen
dc.date.issued2023-07-01en
dc.description.abstractProgressive age-induced deterioration in the structure and function of the cardiovascular system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial stiffness, and endothelial dysfunction. These changes are driven by complex processes that are interconnected, such as oxidative stress, mitochondrial dysfunction, autophagy, inflammation, fibrosis, and telomere dysfunction. In recent years, the advances in research of cardiovascular aging, including the wide use of animal models of cardiovascular aging, elucidated an abundance of cell signaling pathways involved in these processes and brought into sight possible interventions, which span from pharmacological agents, such as metformin, sodium-glucose cotransporter 2-inhibitors, rapamycin, dasatinib and quercetin, to lifestyle changes.en
dc.description.versionAccepted versionen
dc.format.extentPages 23en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.20517/jca.2023.09en
dc.identifier.eissn2768-5993en
dc.identifier.issn2768-5993en
dc.identifier.issue3en
dc.identifier.orcidWarren, Junko [0000-0001-5231-4181]en
dc.identifier.otherPMC10238104en
dc.identifier.other23 (PII)en
dc.identifier.pmid37274126en
dc.identifier.urihttps://hdl.handle.net/10919/117854en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherOAE Publishingen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37274126en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCardiovascular agingen
dc.subjectautophagyen
dc.subjectfibrosisen
dc.subjectinflammagingen
dc.subjectmitochondrial dysfunctionen
dc.subjectoxidative stressen
dc.titleCardiovascular aging: from cellular and molecular changes to therapeutic interventionsen
dc.title.serialJournal of Cardiovascular Agingen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Biomedical Research Institute at VTCen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cardiovascular aging from cellular and molecular changes to therapeutic interventions.pdf
Size:
794 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Plain Text
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, Human Nutrition, Foods, and Exercise