Genetic resources for methane production from biomass described with the Gene Ontology

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dc.contributor.authorPurwantini, E.en
dc.contributor.authorTorto-Alalibo, T.en
dc.contributor.authorLomax, J.en
dc.contributor.authorSetubal, João C.en
dc.contributor.authorTyler, B. M.en
dc.contributor.authorMukhopadhyay, B.en
dc.contributor.departmentBiochemistryen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2018-01-08T13:34:33Zen
dc.date.available2018-01-08T13:34:33Zen
dc.date.issued2014-12-03en
dc.description.abstractMethane (CH<sub>4</sub>) is a valuable fuel, constituting 70–95% of natural gas, and a potent greenhouse gas. Release of CH<sub>4</sub> into the atmosphere contributes to climate change. Biological CH<sub>4</sub> production or methanogenesis is mostly performed by methanogens, a group of strictly anaerobic archaea. The direct substrates for methanogenesis are H<sub>2</sub> plus CO<sub>2</sub>, acetate, formate, methylamines, methanol, methyl sulfides, and ethanol or a secondary alcohol plus CO<sub>2</sub>. In numerous anaerobic niches in nature, methanogenesis facilitates mineralization of complex biopolymers such as carbohydrates, lipids and proteins generated by primary producers. Thus, methanogens are critical players in the global carbon cycle. The same process is used in anaerobic treatment of municipal, industrial and agricultural wastes, reducing the biological pollutants in the wastes and generating methane. It also holds potential for commercial production of natural gas from renewable resources. This process operates in digestive systems of many animals, including cattle, and humans. In contrast, in deep-sea hydrothermal vents methanogenesis is a primary production process, allowing chemosynthesis of biomaterials from H<sub>2</sub> plus CO<sub>2</sub>. In this report we present Gene Ontology (GO) terms that can be used to describe processes, functions and cellular components involved in methanogenic biodegradation and biosynthesis of specialized coenzymes that methanogens use. Some of these GO terms were previously available and the rest were generated in our Microbial Energy Gene Ontology (MENGO) project. A recently discovered non-canonical CH<sub>4</sub> production process is also described. We have performed manual GO annotation of selected methanogenesis genes, based on experimental evidence, providing “gold standards” for machine annotation and automated discovery of methanogenesis genes or systems in diverse genomes.en
dc.description.versionPublished versionen
dc.format.extent18 pagesen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2014.00634en
dc.identifier.issn1664-302Xen
dc.identifier.urihttp://hdl.handle.net/10919/81600en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346372200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiologyen
dc.subjectGene Ontologyen
dc.subjectbiomassen
dc.subjectbiodegradationen
dc.subjectmethanogenesisen
dc.subjectmethanogenen
dc.subjectbioenergyen
dc.subjectcarbon cycleen
dc.subjectwaste treatmenten
dc.subjectCOENZYME-M METHYLTRANSFERASEen
dc.subjectTHERMOAUTOTROPHICUM STRAIN MARBURGen
dc.subjectMETHANOSARCINA-ACETIVORANS C2Aen
dc.subjectARCHAEON METHANOCOCCUS-MARIPALUDISen
dc.subjectM METHYL TRANSFERen
dc.subjectMETHANOBACTERIUM-THERMOAUTOTROPHICUMen
dc.subjectMETHANOGENIC ARCHAEAen
dc.subjectCARBON-MONOXIDEen
dc.subjectENERGY-CONSERVATIONen
dc.subjectANAEROBIC-DIGESTIONen
dc.titleGenetic resources for methane production from biomass described with the Gene Ontologyen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistryen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Facultyen

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