Non-Coding RNAs in Human Health and Diseases

dc.contributor.authorGood, Deborah J.en
dc.date.accessioned2023-07-28T14:46:49Zen
dc.date.available2023-07-28T14:46:49Zen
dc.date.issued2023-07-11en
dc.date.updated2023-07-28T12:21:43Zen
dc.description.abstractNon-coding RNAs (ncRNAs) are, arguably, the enigma of the RNA transcriptome. Even though there are more annotated ncRNAs (25,967) compared to mRNAs (19,827), we know far less about each of the genes that produce ncRNA, especially in terms of their regulation, molecular functions, and interactions. Further, we are only beginning to understand the role of differential regulation or function of ncRNAs caused by genetic and epigenetic perturbations, such as single nucleotide variants (SNV), deletions, insertions, and histone/DNA modifications. The 22 papers in this Special Issue describe the emerging roles of ncRNAs in neurological, cardiovascular, immune, and hepatic systems, to name a few, as well as in diseases such as cancer, Prader–Willi Syndrome, cardiac arrhythmias, and diabetes. As we begin to understand the function and regulation of this class of RNAs, strategies targeting ncRNAs could lead to improved therapeutic interventions for some conditions.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGood, D.J. Non-Coding RNAs in Human Health and Diseases. Genes 2023, 14, 1429.en
dc.identifier.doihttps://doi.org/10.3390/genes14071429en
dc.identifier.urihttp://hdl.handle.net/10919/115916en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectncRNAen
dc.subjectmicroRNAen
dc.subjectlong non-coding RNAen
dc.subjectpiwi RNAen
dc.subjectcircular RNAen
dc.subjectsno RNAen
dc.subjectsmall non-coding RNAen
dc.titleNon-Coding RNAs in Human Health and Diseasesen
dc.title.serialGenesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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