Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali

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dc.contributor.authorZambrana, Luis E.en
dc.contributor.authorMcKeen, Starinen
dc.contributor.authorIbrahim, Henden
dc.contributor.authorZarei, Imanen
dc.contributor.authorBorresen, Erica C.en
dc.contributor.authorDoumbia, Lassinaen
dc.contributor.authorBore, Abdoulayeen
dc.contributor.authorCissoko, Alimaen
dc.contributor.authorDouyon, Seydouen
dc.contributor.authorKone, Karimen
dc.contributor.authorPerez, Johannen
dc.contributor.authorPerez, Claudia E.en
dc.contributor.authorHess, Annen
dc.contributor.authorAbdo, Zaiden
dc.contributor.authorSangare, Lansanaen
dc.contributor.authorMaiga, Ababacaren
dc.contributor.authorBecker-Dreps, Sylviaen
dc.contributor.authorYuan, Lijuanen
dc.contributor.authorKoita, Ousmaneen
dc.contributor.authorVilchez, Samuelen
dc.contributor.authorRyan, Elizabeth P.en
dc.date.accessioned2019-11-19T14:04:38Zen
dc.date.available2019-11-19T14:04:38Zen
dc.date.issued2019-09-26en
dc.description.abstractRice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1-5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6-8 and 8-12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent.en
dc.description.notesThe authors thank the study participants, community health workers, and local clinical staff for their assistance in the conduct of the clinical trials. This study was supported by the Grand Challenges Explorations in Global Health award from the Bill and Melinda Gates Foundation (OPP1043255) and the Fulbright Faculty Development scholarship award.en
dc.description.sponsorshipGrand Challenges Explorations in Global Health award from the Bill and Melinda Gates Foundation [OPP1043255]; Fulbright Faculty Development scholarship awarden
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-019-50344-4en
dc.identifier.eissn2045-2322en
dc.identifier.other13919en
dc.identifier.pmid31558739en
dc.identifier.urihttp://hdl.handle.net/10919/95805en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleRice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Malien
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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