Supratentorial Cortical Ependymoma: A Systematic Literature Review and Case Illustration

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dc.contributor.authorCuoco, Joshua A.en
dc.contributor.authorStrohman, Andrew C.en
dc.contributor.authorStopa, Brittany M.en
dc.contributor.authorStump, Michael S.en
dc.contributor.authorEntwistle, John J.en
dc.contributor.authorWitcher, Mark R.en
dc.contributor.authorOlasunkanmi, Adeolu L.en
dc.date.accessioned2022-08-30T14:50:41Zen
dc.date.available2022-08-30T14:50:41Zen
dc.date.issued2022-06-01en
dc.date.updated2022-08-30T14:29:07Zen
dc.description.abstractCortical ependymomas are currently not considered a subgroup of supratentorial ependymomas; however, there is a growing body of literature investigating the natural history of these lesions compared to supratentorial ependymomas. We performed a systematic literature review of cortical ependymomas with a focus on the natural history, clinical characteristics, and clinical outcomes of these lesions as compared to supratentorial ependymomas. Our search revealed 153 unique cases of cortical ependymomas. The mean age on presentation was 21.2 years. Males and females comprised 58.8% (90/153) and 41.2% (63/153) of cases, respectively. The most common presenting symptom was seizure activity occurring in 44.4% of the cohort (68/153). The recently recognized C11orf95-RELA fusion was identified in 13.7% of the cohort (21/153) and 95.5% of cases (21/22) reporting molecular characterization. World Health Organization grades 2 and 3 were reported in 52.3% (79/151) and 47.7% (72/151) of cases, respectively. The frontal lobe was involved in the majority of cases (54.9%, 84/153). Gross total resection was achieved in 80.4% of cases (123/153). Tumor recurrence was identified in 27.7% of cases (39/141). Mean clinical follow-up was 41.3 months. Mean overall survival of patients who expired was 27.4 months whereas mean progression-free survival was 15.0 months. Comparatively, cortical ependymomas with C11orf95-RELA fusions and supratentorial ependymomas with C11orf95 RELA fusions exhibited differing clinical outcomes. Further studies with larger sample sizes are necessary to investigate the significance of RELA fusions on survival in cortical ependymomas and to determine whether cortical ependymomas with C11orf95-RELA fusions should be classified as a distinct entity.en
dc.description.notesPMID: 35836750en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1177/20363613221112432en
dc.identifier.eissn2036-3613en
dc.identifier.issn2036-3605en
dc.identifier.orcidWitcher, Mark [0000-0001-6877-2670]en
dc.identifier.orcidCuoco, Joshua [0000-0002-7118-3890]en
dc.identifier.otherPMC9274435en
dc.identifier.other10.1177_20363613221112432 (PII)en
dc.identifier.pmid35836750en
dc.identifier.urihttp://hdl.handle.net/10919/111670en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherSAGEen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35836750en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectcortical ependymomaen
dc.subjectependymomaen
dc.subjectinsulaen
dc.subjectinsular ependymomaen
dc.subjectsupratentorial cortical ependymomaen
dc.subjectNeurosciencesen
dc.titleSupratentorial Cortical Ependymoma: A Systematic Literature Review and Case Illustrationen
dc.title.serialRare Tumorsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2022-06-10en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC School of Medicine - Instr Pgmsen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgeryen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgery/Neurosurgeryen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC School of Medicine - Instr Pgms/VTC School of Medicine-Instr Pgmsen

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