The Shifting Landscape of Lupus Nephritis Management: A Review

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dc.contributor.authorBankole, Adegbenga A.en
dc.contributor.authorNwaonu, Jane N.en
dc.date.accessioned2022-02-18T18:29:41Zen
dc.date.available2022-02-18T18:29:41Zen
dc.date.issued2022-01-05en
dc.date.updated2022-02-18T18:29:39Zen
dc.description.abstractSystemic lupus erythematosus (SLE) is commonly the first autoimmune disease that comes to mind for most people when rheumatology is mentioned. It remains an enigma that many of us, including patients and healthcare providers, do not fully understand. Although an ancient disease, it still remains difficult to both diagnose and treat. Historically, there has always been a paucity of therapeutic interventions for SLE as a whole. One of the most distressing manifestations for the patient and diagnostic and therapeutically challenging aspects of SLE is lupus nephritis (LN). There has historically been some difficultly in the development of LN drugs that provide significant therapeutic benefits while having an acceptable side-effect profile. This difficulty led to decades in which no drugs were approved for LN. With a better understanding of the pathogenesis of SLE and LN and improvement in trial design, great therapeutic strides have recently been made. The immunosuppressive landscape of LN has changed recently with the approval of two newer agents as well as a number of promising trials in LN. With the increased number of therapeutic agents (both immunosuppressive and non-immunosuppressive), the clinical question is how and when to use these medications, and, more importantly, which agents to use first. With the increased number of agents, the answers to these questions are becoming more difficult to answer. The purpose of the paper is to review updates in LN diagnosis and management.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.7759/cureus.20950en
dc.identifier.issn2168-8184en
dc.identifier.issue1en
dc.identifier.orcidNwaonu, Jane [0000-0002-9379-2275]en
dc.identifier.orcidBankole, Adegbenga [0000-0001-6464-5367]en
dc.identifier.urihttp://hdl.handle.net/10919/108749en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherCureusen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subject11 Medical and Health Sciencesen
dc.titleThe Shifting Landscape of Lupus Nephritis Management: A Reviewen
dc.title.serialCureusen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Rheumatologyen

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