Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning

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dc.contributor.authorLonergan, Mary E.en
dc.contributor.authorGafford, Georgette M.en
dc.contributor.authorJarome, Timothy J.en
dc.contributor.authorHelmstetter, Fred J.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2018-11-19T18:32:14Zen
dc.date.available2018-11-19T18:32:14Zen
dc.date.issued2010en
dc.description.abstractMemory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity underlying learning and memory. This study explored the temporal expression profiles of these proteins in the rat hippocampus following fear conditioning. We observed a timedependent increase of Arc protein in the dorsal hippocampus 30-to-90-minute post training, returning to basal levels at 4 h. Zif268 protein levels, however, gradually increased at 30-minute post training before peaking in expression at 60 minute. The timing of hippocampal Arc and zif268 expression coincides with the critical period for protein synthesis-dependent memory consolidation following fear conditioning. However, the expression of Arc protein appears to be driven by context exploration, whereas, zif268 expression may be more specifically related to associative learning. These findings suggest that altered Arc and zif268 expression are related to neural plasticity during the formation of fear memory.en
dc.description.sponsorshipNational Institute of Mental Healthen
dc.description.sponsorshipNIMH: MH069558en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMary E. Lonergan, Georgette M. Gafford, Timothy J. Jarome, Fred J. Helmstetter, "Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning", Neural Plasticity, vol. 2010, Article ID 139891, 12 pages, 2010. https://doi.org/10.1155/2010/139891en
dc.identifier.doihttps://doi.org/10.1155/2010/139891en
dc.identifier.urihttp://hdl.handle.net/10919/85903en
dc.identifier.volume2010en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.titleTime-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioningen
dc.title.serialNeural Plasticityen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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