Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

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dc.contributor.authorEsmaili, Mansooreen
dc.contributor.authorBrown, Chanelle J.en
dc.contributor.authorShaykhutdinov, Rustemen
dc.contributor.authorAcevedo-Morantes, Claudiaen
dc.contributor.authorWang, Yong Liangen
dc.contributor.authorWille, Holgeren
dc.contributor.authorGandour, Richard D.en
dc.contributor.authorTurner, S. Richarden
dc.contributor.authorOverduin, Michaelen
dc.contributor.departmentChemistryen
dc.contributor.departmentMacromolecules Innovation Instituteen
dc.date.accessioned2020-12-15T13:52:07Zen
dc.date.available2020-12-15T13:52:07Zen
dc.date.issued2020-08-28en
dc.description.abstractMethylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with similar to 20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.en
dc.description.notesThis work was supported by NSERC RGPIN-2018-04994, Campus Alberta Innovation Program (RCP-12-002C), Alberta Prion Research Institute/Alberta Innovates Bio Solutions (201600018) (M.O.) and National Science Foundation DMR-1609379 (S.R.T.) grants. NANUC was supported by TMIC, CFI and Genome Canada. We thank Russell Bishop for discussions and the PagP expression construct.en
dc.description.sponsorshipNSERCNatural Sciences and Engineering Research Council of Canada [RGPIN-2018-04994]; Campus Alberta Innovation Program [RCP-12-002C]; Alberta Prion Research Institute/Alberta Innovates Bio Solutions [201600018]; National Science FoundationNational Science Foundation (NSF) [DMR-1609379]; CFICanada Foundation for Innovation; Genome CanadaGenome Canada; TMICen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1039/d0nr03435een
dc.identifier.eissn2040-3372en
dc.identifier.issn2040-3364en
dc.identifier.issue32en
dc.identifier.pmid32780785en
dc.identifier.urihttp://hdl.handle.net/10919/101349en
dc.identifier.volume12en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.titleHomogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymersen
dc.title.serialNanoscaleen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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