Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

dc.contributor.authorShrestha, Dhan Bahaduren
dc.contributor.authorSedhai, Yub Rajen
dc.contributor.authorDawadi, Sagunen
dc.contributor.authorDhakal, Bishalen
dc.contributor.authorShtembari, Jurgenen
dc.contributor.authorSingh, Karanen
dc.contributor.authorAcharya, Roshanen
dc.contributor.authorBasnyat, Soneyen
dc.contributor.authorWaheed, Irfanen
dc.contributor.authorKhan, Mohammad Sauden
dc.contributor.authorKazimuddin, Mohammeden
dc.contributor.authorPatel, Nimesh K.en
dc.contributor.authorKalahasty, Gauthamen
dc.contributor.authorBhave, Prashant Dattatrayaen
dc.contributor.authorWhalen, Patricken
dc.contributor.authorShantha, Ghanshyamen
dc.date.accessioned2023-04-12T16:28:25Zen
dc.date.available2023-04-12T16:28:25Zen
dc.date.issued2023-04-10en
dc.date.updated2023-04-12T13:24:32Zen
dc.description.abstractBackground: Outcomes following in-hospital cardiac arrest (IHCA) in patients with COVID-19 have been reported by several small single-institutional studies; however, there are no large studies contrasting COVID-19 IHCA with non-COVID-19 IHCA. The objective of this study was to compare the outcomes following IHCA between COVID-19 and non-COVID-19 patients. Methods: We searched databases using predefined search terms and appropriate Boolean operators. All the relevant articles published till August 2022 were included in the analyses. The systematic review and meta-analysis were conducted as per Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. An odds ratio with a 95% confidence interval (CI) was used to measure effects. Results: Among 855 studies screened, 6 studies with 27,453 IHCA patients (63.84% male) with COVID-19 and 20,766 (59.7% male) without COVID-19 were included in the analysis. IHCA among patients with COVID-19 has lower odds of achieving return of spontaneous circulation (ROSC) (OR: 0.66, 95% CI: 0.62–0.70). Similarly, patients with COVID-19 have higher odds of 30-day mortality following IHCA (OR: 2.26, 95% CI: 2.08–2.45) and have 45% lower odds of cardiac arrest because of a shockable rhythm (OR: 0.55, 95% CI: 0.50–0.60) (9.59% vs. 16.39%). COVID-19 patients less commonly underwent targeted temperature management (TTM) or coronary angiography; however, they were more commonly intubated and on vasopressor therapy as compared to patients who did not have a COVID-19 infection. Conclusions: This meta-analysis showed that IHCA with COVID-19 has a higher mortality and lower rates of ROSC compared with non-COVID-19 IHCA. COVID-19 is an independent risk factor for poor outcomes in IHCA patients.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationShrestha, D.B.; Sedhai, Y.R.; Dawadi, S.; Dhakal, B.; Shtembari, J.; Singh, K.; Acharya, R.; Basnyat, S.; Waheed, I.; Khan, M.S.; Kazimuddin, M.; Patel, N.K.; Kalahasty, G.; Bhave, P.D.; Whalen, P.; Shantha, G. Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis. J. Clin. Med. 2023, 12, 2796.en
dc.identifier.doihttps://doi.org/10.3390/jcm12082796en
dc.identifier.urihttp://hdl.handle.net/10919/114488en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleOutcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysisen
dc.title.serialJournal of Clinical Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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