Dosing parameters for the effects of high-frequency transcranial magnetic stimulation on smoking cessation: Study protocol for a randomized factorial sham-controlled clinical trial

dc.contributor.authorCarl, Ellenen
dc.contributor.authorLiskiewicz, Amylynnen
dc.contributor.authorRivard, Cherylen
dc.contributor.authorAlberico, Ronalden
dc.contributor.authorBelal, Ahmeden
dc.contributor.authorMahoney, Martin C.en
dc.contributor.authorQuisenberry, Amanda J.en
dc.contributor.authorBickel, Warren K.en
dc.contributor.authorSheffer, Christine E.en
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2021-09-24T16:46:43Zen
dc.date.available2021-09-24T16:46:43Zen
dc.date.issued2020-05-01en
dc.date.updated2021-09-24T16:46:40Zen
dc.description.abstractBackground: Despite the considerable success of comprehensive tobacco control efforts, tobacco use remains one of the greatest preventable causes of death and disease today. Over half of all smokers in the US make quit attempts every year, but over 90% relapse within 12 months, choosing the immediate reinforcement of smoking over the long-term benefits of quitting. Conceptual and empirical evidence supports continued investigation of high frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex in reducing relapse and decreasing cigarette consumption. While this evidence is compelling, an optimal dosing strategy must be determined before a long-term efficacy trial can be conducted. The goal of this study is to determine a dosing strategy for 20 Hz rTMS that will produce the best long-term abstinence outcomes with the fewest undesirable effects. Methods: This is a fully crossed, double-blinded, sham-controlled, 3x2x2 randomized factorial study. The three factors are duration (stimulation days: 8, 12, and 16); intensity (900 or 1800 pulses per day); and sham control. Participants (n = 258) will consist of adults (18-65) who are motivated to quit smoking cigarettes and who will be followed for 6 months post-quit. Outcomes include latency to relapse, point prevalence abstinence rates, delay discounting rates, cognitive-behavioral skills acquisition, and multiple measures of potential undesirable effects that impact participant compliance. Discussion: This study integrates existing theoretical concepts and methodologies from neuropsychology, behavioral economics, brain stimulation, clinical psychology, and the evidence-based treatment of tobacco dependence in the development of a promising and innovative approach to treat tobacco dependence. This study will establish an optimal dosing regimen for efficacy testing. Findings are expected to have a significant influence on advancing this approach as well as informing future research on clinical approaches that combine rTMS with other evidence-based treatments for tobacco dependence and perhaps other addictions.en
dc.description.versionPublished versionen
dc.format.extentPages 42en
dc.format.mimetypeapplication/pdfen
dc.identifier42 (Article number)en
dc.identifier.doihttps://doi.org/10.1186/s40359-020-00403-7en
dc.identifier.eissn2050-7283en
dc.identifier.issn2050-7283en
dc.identifier.issue1en
dc.identifier.orcidBickel, Warren [0000-0002-1048-7372]en
dc.identifier.other10.1186/s40359-020-00403-7 (PII)en
dc.identifier.pmid32357940en
dc.identifier.urihttp://hdl.handle.net/10919/105057en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/32357940en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBrain stimulationen
dc.subjectDelay discountingen
dc.subjectDorsolateral prefrontal cortexen
dc.subjectNeuromodulationen
dc.subjectRelapse preventionen
dc.subjectSmoking cessationen
dc.subjectTobacco dependenceen
dc.subjectTranscranial magnetic stimulationen
dc.subject1701 Psychologyen
dc.subject.meshPrefrontal Cortexen
dc.subject.meshHumansen
dc.subject.meshTobacco Use Disorderen
dc.subject.meshRecurrenceen
dc.subject.meshClinical Protocolsen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshSmokingen
dc.subject.meshBehavior, Addictiveen
dc.subject.meshSmoking Cessationen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshMiddle Ageden
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.subject.meshTranscranial Magnetic Stimulationen
dc.titleDosing parameters for the effects of high-frequency transcranial magnetic stimulation on smoking cessation: Study protocol for a randomized factorial sham-controlled clinical trialen
dc.title.serialBMC Psychologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2020-04-05en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Virginia Tech Carilion Research Instituteen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
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