Zampanolide and Dactylolide: Cytotoxic Tubulin-Assembly Agents and Promising Anticancer Leads

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dc.contributorVirginia Tech. Department of Chemistryen
dc.contributorCenter for Drug Discoveryen
dc.contributorCalifornia State University, Fresno. Department of Chemistryen
dc.contributor.authorChen, Qiao-Hongen
dc.contributor.authorKingston, David G. I.en
dc.contributor.departmentChemistryen
dc.date.accessed2015-04-16en
dc.date.accessioned2015-04-20T18:49:34Zen
dc.date.available2015-04-20T18:49:34Zen
dc.date.issued2014-06-19en
dc.description.abstractZampanolide is a marine natural macrolide and a recent addition to the family of microtubule-stabilizing cytotoxic agents. Zampanolide exhibits unique effects on tubulin assembly and is more potent than paclitaxel against several multi-drug resistant cancer cell lines. A high-resolution crystal structure of xB-tubulin in complex with zampanolide explains how taxane-site microtubule-stabilizing agents promote microtubule assemble and stability. This review provides an overview of current developments of zampanolide and its related but less potent analogue dactylolide, covering their natural sources and isolation, structure and conformation, cytotoxic potential, structure_activity studies, mechanism of action, and syntheses.en
dc.description.sponsorshipCalifornia State University (CSU) Fresnoen
dc.description.sponsorshipCalifornia State University (CSU) Fresno. National Institutes of Health RIMI Program - P20MD002732en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChen, Q.-H., & Kingston, D. G. I. (2014). Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads. Natural Product Reports, 31(9), 1202-1226. doi: 10.1039/C4NP00024Ben
dc.identifier.doihttps://doi.org/10.1039/C4NP00024Ben
dc.identifier.issn0265-0568en
dc.identifier.urihttp://hdl.handle.net/10919/51703en
dc.identifier.urlhttp://pubs.rsc.org/en/content/articlelanding/2014/np/c4np00024ben
dc.language.isoen_USen
dc.publisherThe Royal Society of Chemistryen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectZampanolideen
dc.subjectCytotoxic agentsen
dc.subjectMicrotubule stabilizing agentsen
dc.subjectMulti-drug resistanceen
dc.subjectAnti-cancer drugsen
dc.titleZampanolide and Dactylolide: Cytotoxic Tubulin-Assembly Agents and Promising Anticancer Leadsen
dc.title.serialNatural Product Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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