Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc

Simple item page
dc.contributor.authorKoch, Timothy R.en
dc.contributor.authorZubowicz, Elizabeth A.en
dc.contributor.authorGross, John B., Jr.en
dc.date.accessioned2022-08-09T20:58:18Zen
dc.date.available2022-08-09T20:58:18Zen
dc.date.issued2019-06-04en
dc.date.updated2022-08-06T21:01:32Zen
dc.description.abstractA 30-year-old female underwent vertical sleeve gastrectomy. Postoperatively, hypercupremia and elevated ceruloplasmin were identified. Further testing revealed normal blood levels of transaminases, alkaline phosphatase, and albumin. She stopped ingestion of multivitamins, began a copper-free multivitamin, and then began a low copper diet, but with no improvement in hypercupremia. Protein electrophoresis was normal with no M-spike. Urinary copper excretion was normal at 0.24 micromol/24 hours (normal: < 0.55), and there were no Kayser-Fleischer rings on slit lamp examination. Two years postoperatively, she lost 44% of excess preoperative weight and she began zinc sulfate before meals twice daily (115 mg elemental Zinc/day). At 2 months and 8 months later, plasma copper and ceruloplasmin had essentially normalized. Increased production of ceruloplasmin could have been a response to significant weight loss or the presence of nonalcoholic steatohepatitis. The mechanism of zinc’s beneficial effect is uncertain but may be related to suppressing hepatic synthesis of or secretion of ceruloplasmin.en
dc.description.versionPublished versionen
dc.format.extentPages 1-4en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1155/2019/8175376en
dc.identifier.eissn2090-6536en
dc.identifier.issn2090-6528en
dc.identifier.orcidKoch, Timothy [0000-0002-8026-9653]en
dc.identifier.urihttp://hdl.handle.net/10919/111498en
dc.identifier.volume2019en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleProlonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zincen
dc.title.serialCase Reports in Gastrointestinal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/General IMen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CRIGM2019-8175376.pdf
Size:
667.12 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

All Faculty Deposits
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)