A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques

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dc.contributor.authorCiupe, Stanca M.en
dc.contributor.authorMiller, Christopher J.en
dc.contributor.authorForde, Jonathan E.en
dc.contributor.departmentMathematicsen
dc.date.accessioned2018-07-24T17:01:37Zen
dc.date.available2018-07-24T17:01:37Zen
dc.date.issued2018-06-06en
dc.description.abstractExperimental studies have shown that the size and infectious-stage of viral inoculum influence disease outcomes in rhesus macaques infected with simian immunodeficiency virus. The possible contribution to disease outcome of antibody developed after transmission and/or present in the inoculum in free or bound form is not understood. In this study, we develop a mathematical model of virus-antibody immune complex formation and use it to predict their role in transmission and protection. The model exhibits a bistable switch between clearance and persistence states. We fitted it to temporal virus data and estimated the parameter values for free virus infectivity rate and antibody carrying capacity for which the model transitions between virus clearance and persistence when the initial conditions (in particular the ratio of immune complexes to free virus) vary. We used these results to quantify the minimum virus amount in the inoculum needed to establish persistent infections in the presence and absence of protective antibodies.en
dc.description.sponsorshipNational Science Foundationen
dc.description.sponsorshipNSF:DMS-1214582en
dc.description.sponsorshipNSF: DMS- 1813011en
dc.description.sponsorshipSimons Foundationen
dc.description.sponsorshipSF: 427115en
dc.description.sponsorshipNational Center for Research Resourcesen
dc.description.sponsorshipNCRR:U51RR00169en
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen
dc.description.sponsorshipNIAID: P01 AI066314en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2018.01216en
dc.identifier.urihttp://hdl.handle.net/10919/84312en
dc.identifier.volume9en
dc.language.isoen_USen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectSIVen
dc.subjectimmune complexesen
dc.subjectmathematical modelen
dc.subjectbistable dynamicsen
dc.subjectstochastic modelen
dc.titleA Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaquesen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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