Histopathologic Variation between Liver Lobes in Dogs

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dc.contributor.authorKemp, Stephanie D.en
dc.contributor.authorZimmerman, Kurt L.en
dc.contributor.authorPanciera, David L.en
dc.contributor.authorMonroe, William E.en
dc.contributor.authorLeib, Michael S.en
dc.date.accessioned2019-08-08T12:44:50Zen
dc.date.available2019-08-08T12:44:50Zen
dc.date.issued2015-01en
dc.description.abstractBackground: Biopsy of the liver evaluates a small portion of tissue, with inferences made to the entire organ. The method and number of biopsies obtained are tempered by consideration of the risks and benefits. Recommendations often include biopsy of more than one liver lobe, although the consistency of histopathology among lobes in dogs is unknown. Hypothesis/Objectives: To describe the distribution of histopathologic abnormalities between liver lobes. We hypothesized that discordant results would be evenly distributed among all liver lobes. Animals: Seventy dogs undergoing necropsy. Methods: Prospective study. Liver samples were obtained from all lobes. A primary diagnosis was assigned to each liver sample based on the predominant histopathologic abnormality. Results: In this population of dogs, biopsy of at least 2 liver lobes identified the predominant histologic abnormality in 98.6% of the cases. Ten ( 14%) of the dogs had = 3 lobes in agreement and could not be assigned a predominant diagnosis. The same diagnosis was present in 6/ 6 lobes in 39 ( 56.5%) dogs, 5/ 6 lobes in 10 ( 14.5%) dogs, 4/ 6 lobes in 10 ( 14.5%) dogs, 3/ 6 lobes in 7 ( 10.1%) dogs, and 2/ 6 in 3 ( 4.3%) dogs. The number of discordant results did not differ between the liver lobes. Conclusion and Clinical Importance: The likelihood of obtaining a sample that is reflective of the predominant histologic abnormality in the liver is increased when multiple liver lobes are biopsied.en
dc.description.notesThe study was funded by the Virginia Veterinary Memorial Fund.en
dc.description.sponsorshipVirginia Veterinary Memorial Funden
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.12520en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue1en
dc.identifier.pmid25581717en
dc.identifier.urihttp://hdl.handle.net/10919/92887en
dc.identifier.volume29en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Internal Medicineen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectFibrosisen
dc.subjectHepatitisen
dc.subjectLiver biopsyen
dc.titleHistopathologic Variation between Liver Lobes in Dogsen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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